L-Phenylalanine, N-(2,6-dichlorobenzoyl)-4-[1,4-dihydro-1-methyl-6-[(methylamino)methyl ]-2,4-dioxo-3(2H)-quinazolinyl]-, 1-methylethyl ester, (2Z)-2-butenedioate (1:1)

Base Information

Chemical Name:L-Phenylalanine, N-(2,6-dichlorobenzoyl)-4-[1,4-dihydro-1-methyl-6-[(methylamino)methyl ]-2,4-dioxo-3(2H)-quinazolinyl]-, 1-methylethyl ester, (2Z)-2-butenedioate (1:1)
CAS No.:917885-99-5
Molecular Formula:C₄H₄O₄*C₃₀H₃₀Cl₂N₄O₅
Molecular Weight:713.571
Hs Code.:

L-Phenylalanine,
N-(2,6-dichlorobenzoyl)-4-[1,4-dihydro-1-methyl-6-[(methylamino)methyl
]-2,4-dioxo-3(2H)-quinazolinyl]-, 1-methylethyl ester,
(2Z)-2-butenedioate (1:1)

Synonyms:

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Chemical Property of L-Phenylalanine, N-(2,6-dichlorobenzoyl)-4-[1,4-dihydro-1-methyl-6-[(methylamino)methyl ]-2,4-dioxo-3(2H)-quinazolinyl]-, 1-methylethyl ester, (2Z)-2-butenedioate (1:1)

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Technology Process of L-Phenylalanine, N-(2,6-dichlorobenzoyl)-4-[1,4-dihydro-1-methyl-6-[(methylamino)methyl ]-2,4-dioxo-3(2H)-quinazolinyl]-, 1-methylethyl ester, (2Z)-2-butenedioate (1:1)

There total 10 articles about L-Phenylalanine, N-(2,6-dichlorobenzoyl)-4-[1,4-dihydro-1-methyl-6-[(methylamino)methyl ]-2,4-dioxo-3(2H)-quinazolinyl]-, 1-methylethyl ester, (2Z)-2-butenedioate (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 857870-47-4
4-amino-Nα-(2,6-dichlorobenzoyl)-L-phenylalanine isopropyl ester

: 917885-99-5
C₄H₄O₄*C₃₀H₃₀Cl₂N₄O₅

Guidance literature:: Multi-step reaction with 8 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; N,N-dimethyl-formamide / 16 h / 0 - 20 °C

2.1: N,N-dimethyl-formamide / 20 - 80 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

4.1: triethylamine / palladium diacetate / water; N,N-dimethyl-formamide / 11 h / 70 °C

5.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

5.2: 1 h / 0 °C

6.1: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 - 20 °C

7.1: tetrahydrofuran; acetonitrile / 10 h / 20 °C

8.1: ethyl acetate / 69.5 - 72.5 h / 5 - 60 °C

With chloroformic acid ethyl ester; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; palladium diacetate; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 401906-14-7
Nα-(2,6-dichlorobenzoyl)-4-nitro-L-phenylalanine

: 917885-99-5
C₄H₄O₄*C₃₀H₃₀Cl₂N₄O₅

Guidance literature:: Multi-step reaction with 10 steps

1.1: sulfuric acid / tetrahydrofuran / 120 h / 50 °C

2.1: hydrogen / 3percent Pt-S/C / tetrahydrofuran; isopropyl alcohol / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; N,N-dimethyl-formamide / 16 h / 0 - 20 °C

4.1: N,N-dimethyl-formamide / 20 - 80 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

6.1: triethylamine / palladium diacetate / water; N,N-dimethyl-formamide / 11 h / 70 °C

7.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

7.2: 1 h / 0 °C

8.1: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 - 20 °C

9.1: tetrahydrofuran; acetonitrile / 10 h / 20 °C

10.1: ethyl acetate / 69.5 - 72.5 h / 5 - 60 °C

With sulfuric acid; hydrogen; chloroformic acid ethyl ester; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; palladium diacetate; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 857870-28-1
4-[(2-amino-5-iodobenzoyl)amino]-N-(2,6-dichlorobenzoyl)-L-phenylalanine isopropyl ester

: 917885-99-5
C₄H₄O₄*C₃₀H₃₀Cl₂N₄O₅

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide / 20 - 80 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

3.1: triethylamine / palladium diacetate / water; N,N-dimethyl-formamide / 11 h / 70 °C

4.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

4.2: 1 h / 0 °C

5.1: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 - 20 °C

6.1: tetrahydrofuran; acetonitrile / 10 h / 20 °C

7.1: ethyl acetate / 69.5 - 72.5 h / 5 - 60 °C

With chloroformic acid ethyl ester; potassium carbonate; triethylamine; trichlorophosphate; palladium diacetate; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;