Benzamide, 3-[[1-(methylsulfonyl)-3-pyrrolidinyl]oxy]-4-nitro-

Base Information

Chemical Name:Benzamide, 3-[[1-(methylsulfonyl)-3-pyrrolidinyl]oxy]-4-nitro-
CAS No.:917909-64-9
Molecular Formula:C12H15N3O6S
Molecular Weight:329.334
Hs Code.:

Synonyms:Benzamide,3-[[1-(methylsulfonyl)-3-pyrrolidinyl]oxy]-4-nitro;3-(1-methanesulfonyl-pyrrolidin-3-yloxy)-4-nitro-benzamide;

Suppliers and Price of Benzamide, 3-[[1-(methylsulfonyl)-3-pyrrolidinyl]oxy]-4-nitro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 3 raw suppliers

Chemical Property of Benzamide, 3-[[1-(methylsulfonyl)-3-pyrrolidinyl]oxy]-4-nitro-

Chemical Property:

Boiling Point:546.3±60.0 °C(Predicted)
PSA：144.89000
Density:1.53±0.1 g/cm3(Predicted)
LogP:2.53250

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzamide, 3-[[1-(methylsulfonyl)-3-pyrrolidinyl]oxy]-4-nitro-

There total 4 articles about Benzamide, 3-[[1-(methylsulfonyl)-3-pyrrolidinyl]oxy]-4-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 917909-63-8
4-nitro-3-(pyrrolidin-3-yloxy)-benzamide hydrochloride

: 124-63-0
methanesulfonyl chloride

: 917909-64-9
3-(1-methanesulfonyl-pyrrolidin-3-yloxy)-4-nitro-benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 218632-01-0
3-fluoro-4-nitrobenzonitrile

: 917909-64-9
3-(1-methanesulfonyl-pyrrolidin-3-yloxy)-4-nitro-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: urea hydrogen peroxide adduct; potassium carbonate / water; acetone / 24 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 2 h / 0 - 20 °C

3.1: hydrogenchloride / diethyl ether; isopropyl alcohol / 6 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

With hydrogenchloride; urea hydrogen peroxide adduct; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; isopropyl alcohol; acetone;

Reference yield:

: 917909-62-7
3-(5-carbamoyl-2-nitrophenoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 917909-64-9
3-(1-methanesulfonyl-pyrrolidin-3-yloxy)-4-nitro-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / diethyl ether; isopropyl alcohol / 6 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; isopropyl alcohol;