3-(HYDROXYMETHYL)-BENZOIC ACID

Base Information

• Chemical Name: 3-(HYDROXYMETHYL)-BENZOIC ACID
• CAS No.: 28286-79-5
• Molecular Formula: C8H8 O3
• Molecular Weight: 152.15
• Hs Code.: 2916399090
• Mol file: 28286-79-5.mol

Synonyms:m-Toluicacid, a-hydroxy- (6CI);3-(Hydroxymethyl)benzoic acid; m-(Hydroxymethyl)benzoic acid; a-Hydroxy-m-toluic acid

Chemical Property of 3-(HYDROXYMETHYL)-BENZOIC ACID

Chemical Property:

• Vapor Pressure: 9.43E-06mmHg at 25°C
• Melting Point: 114.5-115 °C
• Boiling Point: 358.1°Cat760mmHg
• PKA: 4.20±0.10(Predicted)
• Flash Point: 184.6°C
• PSA: 57.53000
• Density: 1.314g/cm³
• LogP: 0.87710
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-(Hydroxymethyl)benzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(hydroxymethyl)benzoic acid is an intermediate for the synthesis of pesticides and flavors, and a good highlighter for color films.

Technology Process of 3-(HYDROXYMETHYL)-BENZOIC ACID

There total 18 articles about 3-(HYDROXYMETHYL)-BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%

ethyl 3-(hydroxymethyl)benzoate (34841-13-9) → 3-(Hydroxymethyl)benzoic acid (28286-79-5)

Guidance literature:

ethyl 3-(hydroxymethyl)benzoate; With sodium hydroxide; In ethanol; water; at 20 ℃; for 1h;

With hydrogenchloride; In ethanol; water;

Reference yield: 97.0%

m-formylphenyl benzoic acid (619-21-6) → 3-(Hydroxymethyl)benzoic acid (28286-79-5)

Guidance literature:

With formic acid; C₂₀H₂₉ClIrN₄⁽¹⁺⁾*Cl^(1-); In water; at 80 ℃; for 0.333333h; Reagent/catalyst; Concentration; Time; chemoselective reaction;

DOI:10.1039/c7gc01289f

Reference yield: 89.0%

benzene 1,3-dicarboxylic acid monomethyl ester (1877-71-0) → 3-(Hydroxymethyl)benzoic acid (28286-79-5)

Guidance literature:

With lithium triethylborohydride; In tetrahydrofuran; for 3h;

upstream raw materials:

(3-Bromophenyl)methanol

3-<<3'-(Trifluoromethyl)phenoxy>methyl>benzoic acid

3-methoxycarbonylbenzyl bromide

n-butyllithium

Downstream raw materials:

3-Methoxycarbonyl-α-chlor-hydrozimtsaeure-methylester

3-amino-6-(3-hydroxymethyl-phenyl)-pyrazine-2-carboxylic acid methyl ester

C₁₅H₁₄N₂O₄

3-(Chloromethyl)benzoyl chloride