1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 7-(4-chlorophenyl)-8-(4-pyridinyl)-

Base Information

Chemical Name:1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 7-(4-chlorophenyl)-8-(4-pyridinyl)-
CAS No.:917969-49-4
Molecular Formula:C17H11ClN4O
Molecular Weight:322.754
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 7-(4-chlorophenyl)-8-(4-pyridinyl)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 7-(4-chlorophenyl)-8-(4-pyridinyl)-

There total 12 articles about 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 7-(4-chlorophenyl)-8-(4-pyridinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7-(4-chlorophenyl)-2-(methoxymethyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

: 917969-49-4
7-(4-chlorophenyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

Guidance literature:: With trifluoroacetic acid; at 75 ℃; for 15h; Product distribution / selectivity;

Reference yield:

: 52200-48-3
3-bromo-2-chloropyridine

: 917969-49-4
7-(4-chlorophenyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C

1.2: 2.5 h / -78 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 2.5 h / 100 °C

3.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 12 h / 100 °C

4.1: pyridine; hydrazine / 15 h / Heating / reflux

5.1: tetrahydrofuran / 0.75 h / 20 °C

With pyridine; potassium phosphate; sodium carbonate; hydrazine; lithium diisopropyl amide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; toluene;

Reference yield:

: 7-bromo-2-(methoxymethyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

: 917969-49-4
7-(4-chlorophenyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 15 h / Heating / reflux

2: trifluoroacetic acid / 15 h / 75 °C

With potassium carbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water;