3-((7-(4-chlorophenyl)-3-oxo-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)methyl)-6-(trifluoromethyl)picolinoyl chloride

Base Information

Chemical Name:3-((7-(4-chlorophenyl)-3-oxo-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)methyl)-6-(trifluoromethyl)picolinoyl chloride
CAS No.:917969-50-7
Molecular Formula:C₂₅H₁₄Cl₂F₃N₅O₂
Molecular Weight:544.32
Hs Code.:

Synonyms:3-((7-(4-chlorophenyl)-3-oxo-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)methyl)-6-(trifluoromethyl)picolinoyl chloride

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Chemical Property of 3-((7-(4-chlorophenyl)-3-oxo-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)methyl)-6-(trifluoromethyl)picolinoyl chloride

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Technology Process of 3-((7-(4-chlorophenyl)-3-oxo-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)methyl)-6-(trifluoromethyl)picolinoyl chloride

There total 25 articles about 3-((7-(4-chlorophenyl)-3-oxo-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)methyl)-6-(trifluoromethyl)picolinoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-((7-(4-chlorophenyl)-3-oxo-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)methyl)-6-(trifluoromethyl)picolinic acid

: 917969-50-7
3-((7-(4-chlorophenyl)-3-oxo-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)methyl)-6-(trifluoromethyl)picolinoyl chloride

Guidance literature:: With thionyl chloride; In 1,2-dichloro-ethane; at 80 ℃; for 1h;

Reference yield:

: 52200-48-3
3-bromo-2-chloropyridine

: 917969-50-7
3-((7-(4-chlorophenyl)-3-oxo-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)methyl)-6-(trifluoromethyl)picolinoyl chloride

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C

1.2: 2.5 h / -78 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 2.5 h / 100 °C

3.1: pyridine; hydrazine / 16 h / 120 °C

4.1: tetrahydrofuran / 10 h / 0 - 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 70 °C

5.2: 100 °C

6.1: 6 h / 130 °C

7.1: methanol; water; potassium carbonate / 0.5 h / 20 °C

8.1: Dess-Martin periodane / dichloromethane / 0.17 h / 20 °C

9.1: sodium hydroxide; silver nitrate / water; acetonitrile / 1 h / 20 °C

9.2: pH 5

10.1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 80 °C

With pyridine; methanol; sodium hydroxide; thionyl chloride; water; sodium carbonate; potassium carbonate; Dess-Martin periodane; silver nitrate; hydrazine; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 884494-53-5
3-bromo-2-chloro-4-iodopyridine

: 917969-50-7
3-((7-(4-chlorophenyl)-3-oxo-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)methyl)-6-(trifluoromethyl)picolinoyl chloride

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 2.5 h / 100 °C

2.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 12 h / 100 °C

3.1: pyridine; hydrazine / 15 h / Heating / reflux

4.1: tetrahydrofuran / 0.75 h / 20 °C

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 16 h / 20 °C

6.1: 6 h / 130 °C

7.1: methanol; water; potassium carbonate / 0.5 h / 20 °C

8.1: Dess-Martin periodane / dichloromethane / 0.17 h / 20 °C

9.1: sodium hydroxide; silver nitrate / water; acetonitrile / 1 h / 20 °C

9.2: pH 5

10.1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 80 °C

With pyridine; methanol; sodium hydroxide; potassium phosphate; thionyl chloride; water; sodium carbonate; potassium carbonate; Dess-Martin periodane; silver nitrate; triphenylphosphine; hydrazine; diethylazodicarboxylate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; toluene; acetonitrile;