Ethanone, 1-(3-amino-4-methylphenyl)- (9CI)

Base Information

• Chemical Name: Ethanone, 1-(3-amino-4-methylphenyl)- (9CI)
• CAS No.: 17071-24-8
• Molecular Formula: C9H11 N O
• Molecular Weight: 149.192
• Hs Code.: 2922399090
• Mol file: 17071-24-8.mol

Synonyms:Acetophenone,3-amino-4-methyl- (4CI); Acetophenone, 3'-amino-4'-methyl- (6CI,8CI);1-(3-Amino-4-methylphenyl)ethanone; 3-Amino-4-methylacetophenone;3'-Amino-4'-methylacetophenone; NSC 380875

Chemical Property of Ethanone, 1-(3-amino-4-methylphenyl)- (9CI)

Chemical Property:

• Vapor Pressure: 0.000773mmHg at 25°C
• Melting Point: 83 °C
• Boiling Point: 306.4°Cat760mmHg
• PKA: 3.27±0.10(Predicted)
• Flash Point: 139.1°C
• PSA: 43.09000
• Density: 1.069g/cm³
• LogP: 2.36100
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

1-(3-amino-4-methylphenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanone, 1-(3-amino-4-methylphenyl)- (9CI)

There total 9 articles about Ethanone, 1-(3-amino-4-methylphenyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(4-methyl-3-nitro-phenyl)-ethanone (5333-27-7) → 1-(3-amino-4-methylphenyl)ethanone (17071-24-8)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In ethanol; for 3h;

Reference yield: 95.0%

N-(5-acetyl-2-methylphenyl)acetamide (54766-66-4) → 1-(3-amino-4-methylphenyl)ethanone (17071-24-8)

Guidance literature:

With hydrogenchloride; water; In methanol; for 8h; Reflux;

DOI:10.1016/j.bmc.2014.09.052

Reference yield:

para-methylacetophenone (122-00-9) → 1-(3-amino-4-methylphenyl)ethanone (17071-24-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 18.9 percent / nitration

2: 2.45 g / SnCl₂

With tin(ll) chloride;

upstream raw materials:

1-(4-methyl-3-nitro-phenyl)-ethanone

N-(5-acetyl-2-methylphenyl)acetamide

hydrogenchloride

para-methylacetophenone

Downstream raw materials:

N-Morpholinoacetyl-2-methyl-5-ethyl-anilin