4-QUINOLINECARBONYL CHLORIDE,HYDROCHLORIDE(1:1)

Base Information

• Chemical Name: 4-QUINOLINECARBONYL CHLORIDE,HYDROCHLORIDE(1:1)
• CAS No.: 91799-73-4
• Molecular Formula: C10H6ClNO.ClH
• Molecular Weight: 228.078
• Mol file: 91799-73-4.mol

Synonyms:4-QUINOLINECARBONYL CHLORIDE,HYDROCHLORIDE(1:1);4-Quinolinecarboxylic acid chloride hydrochloride;Cinchoninoyl chloride, hydrochloride;

Chemical Property of 4-QUINOLINECARBONYL CHLORIDE,HYDROCHLORIDE(1:1)

Chemical Property:

• Melting Point: 170 °C
• PSA: 29.96000
• LogP: 3.41580

Purity/Quality:

4-QUINOLINECARBONYLCHLORIDE,HYDROCHLORIDE(1:1) 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-QUINOLINECARBONYL CHLORIDE,HYDROCHLORIDE(1:1)

There total 2 articles about 4-QUINOLINECARBONYL CHLORIDE,HYDROCHLORIDE(1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-quinolinic acid (486-74-8) → quinoline-4-carboxylic acid chloride hydrochloride (91799-73-4)

Guidance literature:

With thionyl chloride; In benzene; for 6h; Heating;

DOI:10.1016/0223-5234(92)90032-V

Reference yield:

quinoline-2,4-dicarboxylic acid (5323-57-9) → quinoline-4-carboxylic acid chloride hydrochloride (91799-73-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / diphenyl ether / 0.25 h / 200 - 215 °C

2: 91 percent / SOCl₂ / benzene / 6 h / Heating

With thionyl chloride; In diphenylether; benzene;

DOI:10.1016/0223-5234(92)90032-V

Reference yield: 69.0%

quinoline-4-carboxylic acid chloride hydrochloride (91799-73-4) + (–)-α-terpinyl amine (67895-57-2) → C20H24N2O

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1055/s-0041-1737276

upstream raw materials:

4-quinolinic acid

quinoline-2,4-dicarboxylic acid

Downstream raw materials:

(2R,4S)-N-[1-(3,5-bis-trifluoromethyl-benzoyl)-2-(4-chloro-benzyl)-piperidin-4-yl]-quinoline-4-carboxamide

(S)-N-(4-chlorobenzyl)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide

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