4-Quinolinecarboxamide, N-(1-(3,5-bis(trifluoromethyl)benzoyl)-2-((4-chlorophenyl)methyl)-4-piperidinyl)-, (2R-trans)-

Base Information

Chemical Name:4-Quinolinecarboxamide, N-(1-(3,5-bis(trifluoromethyl)benzoyl)-2-((4-chlorophenyl)methyl)-4-piperidinyl)-, (2R-trans)-
CAS No.:177707-12-9
Molecular Formula:C₃₁H₂₄ClF₆N₃O₂
Molecular Weight:619.994
Hs Code.:
UNII:987K1SBI71
DSSTox Substance ID:DTXSID30432754
Nikkaji Number:J1.376.157D
Wikidata:Q72496501
Pharos Ligand ID:CANGGZUN926M
ChEMBL ID:CHEMBL1765508
Mol file:177707-12-9.mol

Synonyms:NKP 608;quinoline-4-carboxylic acid (1-(3,5-bis-trifluoromethylbenzoyl)-2-(4-chlorobenzyl)piperidin-4-yl)amide;quinoline-4-carboxylic acid trans-(2R,4S)- (1-(3,5-bis-trifluoromethylbenzoyl)-2-(4-chlorobenzyl)piperidin-4-yl)amide

Suppliers and Price of 4-Quinolinecarboxamide, N-(1-(3,5-bis(trifluoromethyl)benzoyl)-2-((4-chlorophenyl)methyl)-4-piperidinyl)-, (2R-trans)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
NKP608 >98%
1 g
$ 4200.00

DC Chemicals
NKP608 >98%
250 mg
$ 2100.00

DC Chemicals
NKP608 >98%
100 mg
$ 1050.00

Crysdot
NKP608 98+%
50mg
$ 687.00

Crysdot
NKP608 98+%
5mg
$ 172.00

Crysdot
NKP608 98+%
10mg
$ 236.00

ChemScene
NKP608 99.89%
5mg
$ 317.00

ChemScene
NKP608 99.89%
10mg
$ 436.00

ChemScene
NKP608 99.89%
50mg
$ 1267.00

Chemenu
N-((2R,4S)-1-(3,5-bis(trifluoromethyl)benzoyl)-2-(4-chlorobenzyl)piperidin-4-yl)quinoline-4-carboxamide 98%
50mg
$ 643.00

Total 14 raw suppliers

Chemical Property of 4-Quinolinecarboxamide, N-(1-(3,5-bis(trifluoromethyl)benzoyl)-2-((4-chlorophenyl)methyl)-4-piperidinyl)-, (2R-trans)-

Chemical Property:

Boiling Point:719.2±60.0 °C(Predicted)
PKA:12.92±0.40(Predicted)
PSA：62.30000
Density:1.44±0.1 g/cm3(Predicted)
LogP:7.90050
XLogP3:7.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:5
Exact Mass:619.1461237
Heavy Atom Count:43
Complexity:950

Purity/Quality:

97% ^*data from raw suppliers

NKP608 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(C(CC1NC(=O)C2=CC=NC3=CC=CC=C23)CC4=CC=C(C=C4)Cl)C(=O)C5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F
Isomeric SMILES:C1CN([C@@H](C[C@H]1NC(=O)C2=CC=NC3=CC=CC=C23)CC4=CC=C(C=C4)Cl)C(=O)C5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F
Recent EU Clinical Trials:A Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial to Investigate the Safety and Efficacy of AV608 in Subjects with Idiopathic Detrusor Overactivity

Technology Process of 4-Quinolinecarboxamide, N-(1-(3,5-bis(trifluoromethyl)benzoyl)-2-((4-chlorophenyl)methyl)-4-piperidinyl)-, (2R-trans)-

There total 2 articles about 4-Quinolinecarboxamide, N-(1-(3,5-bis(trifluoromethyl)benzoyl)-2-((4-chlorophenyl)methyl)-4-piperidinyl)-, (2R-trans)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: