2-Propenoic acid, 3-[7-[3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-1H-indol-4-yl]-2,3- dihydro-3-phenyl-3-benzofuranyl]-, methyl ester, (2Z)-

Base Information

Chemical Name:2-Propenoic acid, 3-[7-[3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-1H-indol-4-yl]-2,3- dihydro-3-phenyl-3-benzofuranyl]-, methyl ester, (2Z)-
CAS No.:918304-74-2
Molecular Formula:C₃₃H₃₄N₂O₅
Molecular Weight:538.643
Hs Code.:

2-Propenoic acid,
3-[7-[3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-1H-indol-4-yl]-2,3-
dihydro-3-phenyl-3-benzofuranyl]-, methyl ester, (2Z)-

Synonyms:

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Chemical Property of 2-Propenoic acid, 3-[7-[3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-1H-indol-4-yl]-2,3- dihydro-3-phenyl-3-benzofuranyl]-, methyl ester, (2Z)-

Chemical Property:

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Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 2-Propenoic acid, 3-[7-[3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-1H-indol-4-yl]-2,3- dihydro-3-phenyl-3-benzofuranyl]-, methyl ester, (2Z)-

There total 5 articles about 2-Propenoic acid, 3-[7-[3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-1H-indol-4-yl]-2,3- dihydro-3-phenyl-3-benzofuranyl]-, methyl ester, (2Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 88738-78-7
bis-(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate

: 918305-10-9
{2-[4-(3-Formyl-3-phenyl-2,3-dihydro-benzofuran-7-yl)-1H-indol-3-yl]-ethyl}-carbamic acid tert-butyl ester

: 918304-74-2
(Z)-3-{7-[3-(2-tert-Butoxycarbonylamino-ethyl)-1H-indol-4-yl]-3-phenyl-2,3-dihydro-benzofuran-3-yl}-acrylic acid methyl ester

Guidance literature:: With 18-crown-6 ether; potassium hexamethylsilazane;
DOI:10.1016/S0040-4039(98)01819-X

Reference yield:

: 217493-25-9
tert-butyl (2-(4-bromo-1H-indol-3-yl)ethyl)carbamate

: 918304-74-2
(Z)-3-{7-[3-(2-tert-Butoxycarbonylamino-ethyl)-1H-indol-4-yl]-3-phenyl-2,3-dihydro-benzofuran-3-yl}-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent / Pd⁽⁰⁾

2: 79 percent / Bu₄NF / tetrahydrofuran

3: 82 percent / pyr*SO₃, DMSO / CH₂Cl₂

4: 79 percent / KHMDS, 18-crown-6

With 18-crown-6 ether; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; potassium hexamethylsilazane; palladium; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(98)01819-X

Reference yield:

: C₂₇H₄₂BO₅Si

: 918304-74-2
(Z)-3-{7-[3-(2-tert-Butoxycarbonylamino-ethyl)-1H-indol-4-yl]-3-phenyl-2,3-dihydro-benzofuran-3-yl}-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent / Pd⁽⁰⁾

2: 79 percent / Bu₄NF / tetrahydrofuran

3: 82 percent / pyr*SO₃, DMSO / CH₂Cl₂

4: 79 percent / KHMDS, 18-crown-6

With 18-crown-6 ether; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; potassium hexamethylsilazane; palladium; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(98)01819-X