{2-[4-(3-Hydroxymethyl-3-phenyl-2,3-dihydro-benzofuran-7-yl)-1H-indol-3-yl]-ethyl}-carbamic acid tert-butyl ester

Base Information

• Chemical Name: {2-[4-(3-Hydroxymethyl-3-phenyl-2,3-dihydro-benzofuran-7-yl)-1H-indol-3-yl]-ethyl}-carbamic acid tert-butyl ester
• CAS No.: 918305-00-7
• Molecular Formula: C₃₀H₃₂N₂O₄
• Molecular Weight: 484.595

Synonyms:{2-[4-(3-Hydroxymethyl-3-phenyl-2,3-dihydro-benzofuran-7-yl)-1H-indol-3-yl]-ethyl}-carbamic acid tert-butyl ester

Chemical Property of {2-[4-(3-Hydroxymethyl-3-phenyl-2,3-dihydro-benzofuran-7-yl)-1H-indol-3-yl]-ethyl}-carbamic acid tert-butyl ester

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Technology Process of {2-[4-(3-Hydroxymethyl-3-phenyl-2,3-dihydro-benzofuran-7-yl)-1H-indol-3-yl]-ethyl}-carbamic acid tert-butyl ester

There total 3 articles about {2-[4-(3-Hydroxymethyl-3-phenyl-2,3-dihydro-benzofuran-7-yl)-1H-indol-3-yl]-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

{2-[4-(3-Phenyl-3-triisopropylsilanyloxymethyl-2,3-dihydro-benzofuran-7-yl)-1H-indol-3-yl]-ethyl}-carbamic acid tert-butyl ester (217493-26-0) → {2-[4-(3-Hydroxymethyl-3-phenyl-2,3-dihydro-benzofuran-7-yl)-1H-indol-3-yl]-ethyl}-carbamic acid tert-butyl ester (918305-00-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(98)01819-X

Reference yield:

tert-butyl (2-(4-bromo-1H-indol-3-yl)ethyl)carbamate (217493-25-9) → {2-[4-(3-Hydroxymethyl-3-phenyl-2,3-dihydro-benzofuran-7-yl)-1H-indol-3-yl]-ethyl}-carbamic acid tert-butyl ester (918305-00-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / Pd⁽⁰⁾

2: 79 percent / Bu₄NF / tetrahydrofuran

With tetrabutyl ammonium fluoride; palladium; In tetrahydrofuran;

DOI:10.1016/S0040-4039(98)01819-X

Reference yield:

C27H42BO5Si → {2-[4-(3-Hydroxymethyl-3-phenyl-2,3-dihydro-benzofuran-7-yl)-1H-indol-3-yl]-ethyl}-carbamic acid tert-butyl ester (918305-00-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / Pd⁽⁰⁾

2: 79 percent / Bu₄NF / tetrahydrofuran

With tetrabutyl ammonium fluoride; palladium; In tetrahydrofuran;

DOI:10.1016/S0040-4039(98)01819-X

upstream raw materials:

{2-[4-(3-Phenyl-3-triisopropylsilanyloxymethyl-2,3-dihydro-benzofuran-7-yl)-1H-indol-3-yl]-ethyl}-carbamic acid tert-butyl ester

tert-butyl (2-(4-bromo-1H-indol-3-yl)ethyl)carbamate

Downstream raw materials:

(Z)-3-{7-[3-(2-tert-Butoxycarbonylamino-ethyl)-1H-indol-4-yl]-3-phenyl-2,3-dihydro-benzofuran-3-yl}-acrylic acid methyl ester

{2-[4-(3-Formyl-3-phenyl-2,3-dihydro-benzofuran-7-yl)-1H-indol-3-yl]-ethyl}-carbamic acid tert-butyl ester

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