Technology Process of Pyrrolo[2,3-b]pyrrolizin-8(1H)-one, 3-bromo-
There total 5 articles about Pyrrolo[2,3-b]pyrrolizin-8(1H)-one, 3-bromo- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 4'-bromo-2'-(pyrrolidin-2-ylcarbonyl)-1'H-1,3'-bipyrrole-1'-carboxylate;
With
trichlorophosphate;
at 70 ℃;
With
sodium hydroxide;
at 80 ℃;
DOI:10.1016/j.bmc.2006.09.022
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 99 percent / 4-chloropyridine hydrochloride / dioxane / 100 °C
2.1: 43 percent / Heating
3.1: 99 percent / 4-dimethylaminopyridine; triethylamine / 25 °C
4.1: phosphorus oxychloride / 70 °C
4.2: 43 percent / aq. sodium hydroxide / 80 °C
With
dmap; 4-chlorpyridine hydrochloride; triethylamine; trichlorophosphate;
In
1,4-dioxane;
1.1: Clauson-Kaas reaction / 4.1: Vilsmeier-Haack reaction;
DOI:10.1016/j.bmc.2006.09.022
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 40 percent / N-bromosuccinimide; acetic acid / CHCl3 / 1.5 h / 20 °C
2.1: 99 percent / 4-chloropyridine hydrochloride / dioxane / 100 °C
3.1: 43 percent / Heating
4.1: 99 percent / 4-dimethylaminopyridine; triethylamine / 25 °C
5.1: phosphorus oxychloride / 70 °C
5.2: 43 percent / aq. sodium hydroxide / 80 °C
With
dmap; N-Bromosuccinimide; 4-chlorpyridine hydrochloride; acetic acid; triethylamine; trichlorophosphate;
In
1,4-dioxane; chloroform;
2.1: Clauson-Kaas reaction / 5.1: Vilsmeier-Haack reaction;
DOI:10.1016/j.bmc.2006.09.022