890656-26-5

Basic information

• Product Name: ethyl 3-amino-4-bromo-1H-pyrrole-2-carboxylate
• Synonyms: ethyl 3-amino-4-bromo-1H-pyrrole-2-carboxylate
• CAS NO: 890656-26-5
• Molecular Formula: C₇H₉BrN₂O₂
• Molecular Weight: 233.06256
• Mol File: 890656-26-5.mol

Chemical Properties

• Melting Point: 92 °C
• Boiling Point: 345.0±37.0 °C(Predicted)
• Appearance: /
• Density: 1.657±0.06 g/cm3(Predicted)
• PKA: 14.26±0.50(Predicted)
• CAS DataBase Reference: ethyl 3-amino-4-bromo-1H-pyrrole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-amino-4-bromo-1H-pyrrole-2-carboxylate(890656-26-5)
• EPA Substance Registry System: ethyl 3-amino-4-bromo-1H-pyrrole-2-carboxylate(890656-26-5)

Safety Data

• Hazardous Substances Data: 890656-26-5(Hazardous Substances Data)

Upstream product

• 252932-48-2 3-amino-2-ethoxycarbonylpyrrole 
• 128-08-5 N-Bromosuccinimide 
• 252932-49-3 3-amino-2-ethoxycarbonylpyrrole hydrochloride 

Downstream Products

• 918331-14-3 3-bromopyrrolo[2,3-b]pyrrolizin-8(1H)-one 

Relevant articles and documents

Synthesis of Novel Pyrazine-Substituted 1 H -Pyrrole-2-carboxamides and Related Tethered Heterocycles

As part of a drug discovery program, 4-pyrazin-2-yl-1H-pyrrole-2-carboxamides were accessed along with a number of bicyclic analogues. Routes to these compounds were largely absent from the scientific literature. The synthesis of a 4-(pyrazin-2-yl)-1H-pyrrole-2-carboxamide and several fused bicyclic analogues all using standard procedures (SNAr, borylation, C C cross couplings, hydrolysis, amide bond formation, cyclisation, halogenation, and alkylation) from readily available starting materials is reported. The synthetic sequences range from 4-2 steps per final compound, with yields of isolated intermediates ranging from 20 to ?100%.

NOVEL PYRROLO [3, 2-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THERAPY

There are disclosed novel compounds of formula (I) wherein R1, R12, L, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing

Synthesis and biological evaluation of novel pyrrolopyrrolizinones as anticancer agents

We herein describe the synthesis of novel 3-(het)aryl-pyrrolo[2,3-b]pyrrolizin-8(1H)-ones starting from commercial (het)aryl-acetonitriles. A more convergent route was also described through the first synthesis of ethyl 3-amino-4-bromo-1H-pyrrole-2-carbox