2-Octenoic acid, 4-hydroxy-7-oxo-, phenylmethyl ester, (2E)-

Base Information

• Chemical Name: 2-Octenoic acid, 4-hydroxy-7-oxo-, phenylmethyl ester, (2E)-
• CAS No.: 918343-89-2
• Molecular Formula: C15H18O4
• Molecular Weight: 262.30100
• Mol file: 918343-89-2.mol

Synonyms:2-Octenoic acid,4-hydroxy-7-oxo-,phenylmethyl ester,(2E);

Chemical Property of 2-Octenoic acid, 4-hydroxy-7-oxo-, phenylmethyl ester, (2E)-

Chemical Property:

• PSA: 63.60000
• LogP: 2.01610

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Octenoic acid, 4-hydroxy-7-oxo-, phenylmethyl ester, (2E)-

There total 8 articles about 2-Octenoic acid, 4-hydroxy-7-oxo-, phenylmethyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(E)-4-Hydroxy-6-(2-methyl-[1,3]dithian-2-yl)-hex-2-enoic acid benzyl ester (918343-88-1) → (E)-4-Hydroxy-7-oxo-oct-2-enoic acid benzyl ester (918343-89-2)

Guidance literature:

With iodine; sodium hydrogencarbonate; In water; acetone; for 0.25h; cooling;

DOI:10.1016/j.tet.2006.09.061

Reference yield:

3,4,5,6-tetrahydro-2H-pyran-2-one (542-28-9,26354-94-9) → (E)-4-Hydroxy-7-oxo-oct-2-enoic acid benzyl ester (918343-89-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / diethyl ether / 0.25 h / -78 °C

2: 98 percent / BF₃*Et₂O / CH₂Cl₂ / 3 h / 20 °C

3: 92 percent / SO₃*pyridine; Et₃N / dimethylsulfoxide; CH₂Cl₂ / 3 h / 20 °C

4: 3.144 g / piperidine / acetonitrile / 15 h / 20 °C

5: 96 percent / NaHCO₃; I₂ / acetone; H₂O / 0.25 h / cooling

With piperidine; pyridine-SO₃ complex; boron trifluoride diethyl etherate; iodine; sodium hydrogencarbonate; triethylamine; In diethyl ether; dichloromethane; water; dimethyl sulfoxide; acetone; acetonitrile;

DOI:10.1016/j.tet.2006.09.061

Reference yield:

6-hydroxy-2-hexanone (21856-89-3) → (E)-4-Hydroxy-7-oxo-oct-2-enoic acid benzyl ester (918343-89-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / BF₃*Et₂O / CH₂Cl₂ / 3 h / 20 °C

2: 92 percent / SO₃*pyridine; Et₃N / dimethylsulfoxide; CH₂Cl₂ / 3 h / 20 °C

3: 3.144 g / piperidine / acetonitrile / 15 h / 20 °C

4: 96 percent / NaHCO₃; I₂ / acetone; H₂O / 0.25 h / cooling

With piperidine; pyridine-SO₃ complex; boron trifluoride diethyl etherate; iodine; sodium hydrogencarbonate; triethylamine; In dichloromethane; water; dimethyl sulfoxide; acetone; acetonitrile;

DOI:10.1016/j.tet.2006.09.061

upstream raw materials:

(E)-4-Hydroxy-6-(2-methyl-[1,3]dithian-2-yl)-hex-2-enoic acid benzyl ester

3,4,5,6-tetrahydro-2H-pyran-2-one

6-hydroxy-2-hexanone

4-(2'-Methyl-1',3'-dithian-2'-yl)butanal