Technology Process of 1,3-Benzenedicarboxylic acid,
4-benzoyl-5-[[(1,1-dimethylethoxy)carbonyl]oxy]-, 1,3-diethyl ester
There total 3 articles about 1,3-Benzenedicarboxylic acid,
4-benzoyl-5-[[(1,1-dimethylethoxy)carbonyl]oxy]-, 1,3-diethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-tert-butoxycarbonyloxy-isophthalic acid diethyl ester;
With
tetramethylpiperidyl magnesium chloride LiCl comlex;
In
tetrahydrofuran;
at 0 ℃;
for 3h;
In
tetrahydrofuran;
at -40 ℃;
for 0.0833333h;
benzoyl chloride;
In
tetrahydrofuran;
at -40 - 20 ℃;
DOI:10.1021/ol0625536
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 95 percent / H2SO4 / Heating
2.1: 95 percent / DMAP / CH2Cl2 / 0 - 20 °C
3.1: tetramethylpiperidyl magnesium chloride LiCl comlex 1:1 / tetrahydrofuran / 3 h / 0 °C
3.2: CuCN*2LiCl / tetrahydrofuran / 0.08 h / -40 °C
3.3: 91 percent / tetrahydrofuran / -40 - 20 °C
With
dmap; tetramethylpiperidyl magnesium chloride LiCl comlex; sulfuric acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ol0625536
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 95 percent / DMAP / CH2Cl2 / 0 - 20 °C
2.1: tetramethylpiperidyl magnesium chloride LiCl comlex 1:1 / tetrahydrofuran / 3 h / 0 °C
2.2: CuCN*2LiCl / tetrahydrofuran / 0.08 h / -40 °C
2.3: 91 percent / tetrahydrofuran / -40 - 20 °C
With
dmap; tetramethylpiperidyl magnesium chloride LiCl comlex;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ol0625536
