2R-7-Aza-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid 7-tert-butyl ester

Base Information

Chemical Name:2R-7-Aza-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid 7-tert-butyl ester
CAS No.:918411-43-5
Molecular Formula:C12H19NO4
Molecular Weight:241.28400
Hs Code.:
Mol file:918411-43-5.mol

Synonyms:2R-7-AZA-BICYCLO[2.2.1]HEPTANE-2,7-DICARBOXYLIC ACID 7-TERT-BUTYL ESTER;

Suppliers and Price of 2R-7-Aza-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid 7-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
2R-7-Aza-bicyclo[2.2.1]heptane-2,7-dicarboxylicacid7-tert-butylester 95
5g
$ 2750.00

American Custom Chemicals Corporation
2R-7-AZA-BICYCLO[2.2.1]HEPTANE-2,7-DICARBOXYLIC ACID 7-TERT-BUTYL ESTER 95.00%
5MG
$ 502.60

Total 4 raw suppliers

Chemical Property of 2R-7-Aza-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid 7-tert-butyl ester

Chemical Property:

Boiling Point:371.0±25.0 °C (760 mmHg)
PSA：66.84000
Density:1.232±0.06 g/cm3 (20 °C, 760 mmHg)
LogP:1.79690

Purity/Quality:

97% ^*data from raw suppliers

2R-7-Aza-bicyclo[2.2.1]heptane-2,7-dicarboxylicacid7-tert-butylester 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2R-7-Aza-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid 7-tert-butyl ester

There total 6 articles about 2R-7-Aza-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid 7-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 163458-37-5,197080-73-2
(1R,2R,4S)-7-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-7-azabicyclo<2.2.1>heptane

: 918411-43-5,1221818-81-0,500556-91-2,711082-67-6
(1R,2R,4S)-7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-2-carboxylic acid

Guidance literature:: (1R,2R,4S)-7-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-7-azabicyclo<2.2.1>heptane; With sodium hydroxide; In methanol; at 20 ℃; for 18h;

With hydrogenchloride; In methanol; water;

Reference yield:

: 918411-41-3
(1R,2R,4S)-2-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester

: 918411-43-5,1221818-81-0,500556-91-2,711082-67-6
(1R,2R,4S)-7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-2-carboxylic acid

Guidance literature:: With lithium hydroxide; In methanol; water; at 45 ℃; for 1h;
DOI:10.1016/j.tet.2006.09.062

Reference yield:

: 181873-33-6
3-bromo-7-aza-bicyclo[2.2.1]hepta-2,5-diene-2,7-dicarboxylic acid 7-tert-butyl ester 2-methyl ester

: 918411-43-5,1221818-81-0,500556-91-2,711082-67-6
(1R,2R,4S)-7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / H₂; Et₃N / Pd/C / methanol / 4 h / 20 °C

2: 100 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 11 h / 20 °C

3: (COCl)2; DMF / CH₂Cl₂ / 24 h / -40 °C

4: NaH / tetrahydrofuran; hexane / 12 h / 20 °C

5: 641 mg / LiOH*H₂O / methanol; H₂O / 1 h / 45 °C

With lithium hydroxide; oxalyl dichloride; hydrogen; sodium hydride; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; water;
DOI:10.1016/j.tet.2006.09.062