endo-7-Boc-7-azabicyclo[2.2.1]heptan-2-yl carboxylic acid methyl ester racemate

Base Information

• Chemical Name: endo-7-Boc-7-azabicyclo[2.2.1]heptan-2-yl carboxylic acid methyl ester racemate
• CAS No.: 197080-73-2
• Molecular Formula: C13H21NO4
• Molecular Weight: 255.31
• Mol file: 197080-73-2.mol

Synonyms:

Chemical Property of endo-7-Boc-7-azabicyclo[2.2.1]heptan-2-yl carboxylic acid methyl ester racemate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

endo-7-tert-Butyl2-methyl7-azabicyclo[2.2.1]heptane-2,7-dicarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of endo-7-Boc-7-azabicyclo[2.2.1]heptan-2-yl carboxylic acid methyl ester racemate

There total 24 articles about endo-7-Boc-7-azabicyclo[2.2.1]heptan-2-yl carboxylic acid methyl ester racemate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-bromo-7-aza-bicyclo[2.2.1]hepta-2,5-diene-2,7-dicarboxylic acid 7-tert-butyl ester 2-methyl ester (181873-33-6) → (+/-)-methyl endo-7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-2-carboxylate (197080-73-2)

Guidance literature:

With hydrogen; sodium hydrogencarbonate; palladium 10% on activated carbon; In ethanol; water; for 2.5h; under 2585.81 Torr;

Reference yield: 98.0%

3-bromo-7-aza-bicyclo[2.2.1]hepta-2,5-diene-2,7-dicarboxylic acid 7-tert-butyl ester 2-methyl ester (181873-33-6) → (+/-) endo-7-tert-butyl 2-methyl 7-azabicyclo[2.2.1]heptane-2,7-dicarboxylate (197080-73-2)

Guidance literature:

With hydrogen; sodium hydrogencarbonate; palladium 10% on activated carbon; In ethanol; water; for 2.5h; under 2585.81 Torr;

Reference yield: 98.0%

3-bromo-7-aza-bicyclo[2.2.1]hepta-2,5-diene-2,7-dicarboxylic acid 7-tert-butyl ester 2-methyl ester (181873-33-6) → (+/-) endo-7-tert-butyl 2-methyl 7-azabicyclo[2.2.1]heptane-2,7-dicarboxylate (197080-73-2)

Guidance literature:

3-bromo-7-aza-bicyclo[2.2.1]hepta-2,5-diene-2,7-dicarboxylic acid 7-tert-butyl ester 2-methyl ester; palladium 10% on activated carbon; In ethanol;

With hydrogen; sodium hydrogencarbonate; In ethanol; water; for 2.5h; under 2585.81 Torr;

upstream raw materials:

(1R,2R,4S)-7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-2-carboxylic acid

diazomethyl-trimethyl-silane

endo-7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-2-carboxylic acid

(1R,2R,4S)-2-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester

Downstream raw materials:

(+/-)-epiboxidine

exo-2-(5-isoxazolyl)-7-azabicyclo[2.2.1]heptane

endo-7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-2-carboxylic acid

(+/-)-7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-2-carboxylic acid