Benzamide, N-[[(2S)-1-[(1-aminocyclopentyl)methyl]-2-pyrrolidinyl]methyl]-4-(difluoro methoxy)-N-[(2E)-3-(2,4-difluorophenyl)-2-methyl-2-propen-1-yl]-3-meth oxy-

Base Information

Chemical Name:Benzamide, N-[[(2S)-1-[(1-aminocyclopentyl)methyl]-2-pyrrolidinyl]methyl]-4-(difluoro methoxy)-N-[(2E)-3-(2,4-difluorophenyl)-2-methyl-2-propen-1-yl]-3-meth oxy-
CAS No.:918414-37-6
Molecular Formula:C30H37F4N3O3
Molecular Weight:563.636
Hs Code.:

Benzamide,
N-[[(2S)-1-[(1-aminocyclopentyl)methyl]-2-pyrrolidinyl]methyl]-4-(difluoro
methoxy)-N-[(2E)-3-(2,4-difluorophenyl)-2-methyl-2-propen-1-yl]-3-meth
oxy-

Synonyms:

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Chemical Property of Benzamide, N-[[(2S)-1-[(1-aminocyclopentyl)methyl]-2-pyrrolidinyl]methyl]-4-(difluoro methoxy)-N-[(2E)-3-(2,4-difluorophenyl)-2-methyl-2-propen-1-yl]-3-meth oxy-

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Technology Process of Benzamide, N-[[(2S)-1-[(1-aminocyclopentyl)methyl]-2-pyrrolidinyl]methyl]-4-(difluoro methoxy)-N-[(2E)-3-(2,4-difluorophenyl)-2-methyl-2-propen-1-yl]-3-meth oxy-

There total 1 articles about Benzamide, N-[[(2S)-1-[(1-aminocyclopentyl)methyl]-2-pyrrolidinyl]methyl]-4-(difluoro methoxy)-N-[(2E)-3-(2,4-difluorophenyl)-2-methyl-2-propen-1-yl]-3-meth oxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-[2-({(4-difluoromethoxy-3-methoxy-benzoyl)-[3-(2,4-difluoro-phenyl)-2-methyl-allyl]-amino}-methyl-pyrrolidin-1-ylmethyl)-cyclopentyl]-carbamic acid tert-butyl ester

: 918414-37-6
N-[1-(1-amino-cyclopentylmethyl)-pyrrolidin-2-ylmethyl]-4-difluoromethoxy-N-[3-(2,4-difluoro-phenyl)-2-methyl-allyl]-3-methoxy-benzamide

Guidance literature:: 1-[2-({(4-difluoromethoxy-3-methoxy-benzoyl)-[3-(2,4-difluoro-phenyl)-2-methyl-allyl]-amino}-methyl-pyrrolidin-1-ylmethyl)-cyclopentyl]-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With sodium carbonate; In dichloromethane; water;

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 918414-37-6
N-[1-(1-amino-cyclopentylmethyl)-pyrrolidin-2-ylmethyl]-4-difluoromethoxy-N-[3-(2,4-difluoro-phenyl)-2-methyl-allyl]-3-methoxy-benzamide

: 4-difluoromethoxy-N-[3-(2,4-difluoro-phenyl)-2-methyl-allyl]-N-[1-(1-dimethylamino-cyclopentylmethyl)-pyrrolidin-2-ylmethyl]-3-methoxy-benzamide hydrochloride

Guidance literature:: formaldehyd; N-[1-(1-amino-cyclopentylmethyl)-pyrrolidin-2-ylmethyl]-4-difluoromethoxy-N-[3-(2,4-difluoro-phenyl)-2-methyl-allyl]-3-methoxy-benzamide; In methanol; at 20 ℃; for 1h;

With sodium cyanoborohydride; In methanol;