1,3,5-Tribenzyl-6-methyl-pyrimidine-2,4-dione

Base Information

Chemical Name:1,3,5-Tribenzyl-6-methyl-pyrimidine-2,4-dione
CAS No.:918631-04-6
Molecular Formula:C26H24N2O2
Molecular Weight:396.489
Hs Code.:
DSSTox Substance ID:DTXSID30475020
Nikkaji Number:J2.397.729J
Wikidata:Q82305238

Synonyms:1,3,5-tribenzyl-6-methyl-pyrimidine-2,4-dione;918631-04-6;DTXSID30475020;1,3,5-Tribenzyl-6-methyluracil;2,4(1H,3H)-Pyrimidinedione, 1,3,5-tribenzyl-6-methyl-

Suppliers and Price of 1,3,5-Tribenzyl-6-methyl-pyrimidine-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3,5-Tribenzyl-6-methyl-pyrimidine-2,4-dione

Chemical Property:

XLogP3:4.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:396.183778013
Heavy Atom Count:30
Complexity:637

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=O)N(C(=O)N1CC2=CC=CC=C2)CC3=CC=CC=C3)CC4=CC=CC=C4

Technology Process of 1,3,5-Tribenzyl-6-methyl-pyrimidine-2,4-dione

There total 6 articles about 1,3,5-Tribenzyl-6-methyl-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 13061-96-6
dihydroxy-methyl-borane

: 1,3-Dibenzyl-6-iodopyrimidine-2,4 (1H,3H)-dione

: 100-44-7
benzyl chloride

: 918631-04-6
1,3,5-tribenzyl-6-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: With C₉H₁₃NO; palladium diacetate; potassium carbonate; In 1,4-dioxane; at 130 ℃; for 48h; Inert atmosphere;

Reference yield: 30.0%

: 918631-02-4
5-bromomethyl-1,3-dibenzyl-6-methyluracil

: 591-50-4
iodobenzene

: 918631-04-6
1,3,5-tribenzyl-6-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: 5-bromomethyl-1,3-dibenzyl-6-methyluracil; With chloro-trimethyl-silane; ethylene dibromide; zinc; In tetrahydrofuran; at 20 ℃;

iodobenzene; With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1080/00397910600772850

Reference yield:

: 362690-43-5
5-benzyloxymethyl-6-methyluracil

: 918631-04-6
1,3,5-tribenzyl-6-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: 57 percent / sodium hydride / dimethylformamide

2.1: 59 percent / HBr; acetic acid / dioxane / 12 h / 20 °C

3.1: zinc; 1,2-dibromoethane; trimethylsilylchloride / tetrahydrofuran / 20 °C

3.2: 30 percent / (o-furyl)3P / bis(dibenzylideneacetone)palladium⁽⁰⁾ / tetrahydrofuran / 12 h / 20 °C

With chloro-trimethyl-silane; hydrogen bromide; sodium hydride; acetic acid; ethylene dibromide; zinc; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1080/00397910600772850