2,5-Dichloro-[1,8]naphthyridine

Base Information

• Chemical Name: 2,5-Dichloro-[1,8]naphthyridine
• CAS No.: 91870-15-4
• Molecular Formula: C8H4Cl2N2
• Molecular Weight: 199.039
• Hs Code.: 2933990090
• Mol file: 91870-15-4.mol

Synonyms:2,5-dichloro-[1,8]naphthyridine;1,8-Naphthyridine,2,5-dichloro;

Chemical Property of 2,5-Dichloro-[1,8]naphthyridine

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Boiling Point: 300.445oC at 760 mmHg
• PKA: 1.76±0.30(Predicted)
• Flash Point: 163.841oC
• PSA: 25.78000
• Density: 1.487g/cm3
• LogP: 2.93660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,5-Dichloro-1,8-naphthyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-Dichloro-[1,8]naphthyridine

There total 5 articles about 2,5-Dichloro-[1,8]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

→ 2,5-dichloro-1,8-naphthyridine (91870-15-4)

Guidance literature:

Reference yield:

1,8-naphthyridine-2,5-diol (37905-96-7) → 2,5-dichloro-1,8-naphthyridine (91870-15-4)

Guidance literature:

With trichlorophosphate; at 120 ℃; for 0.75h;

Reference yield:

6-amino-pyridin-2-ol (5154-00-7,59315-47-8) → 2,5-dichloro-1,8-naphthyridine (91870-15-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.5 h / 110 °C

2: NaOH / H₂O / 1.75 h / 100 °C

3: 2.5 g / diphenyl ether / 9 h / Heating

4: 0.8 g / phosphoryl chloride / 0.75 h / 120 °C

With sodium hydroxide; trichlorophosphate; In diphenylether; water;

upstream raw materials:

1,8-naphthyridine-2,5-diol

6-amino-pyridin-2-ol

diethyl (6'-methylpyridin-2'-yl)aminomethylenemalonate

Downstream raw materials:

4-[2-(7-chloro-[1,8]naphthyridin-4-ylamino)-4-methyl-phenylsulfanyl]-phenol

4-(7'-chloro-1',8'-naphthyridin-4'-ylamino)-2-diethylaminomethylphenol

4-[2-(7-ethoxy-[1,8]naphthyridin-4-ylamino)-4-methyl-phenylsulfanyl]-phenol trifluoroacetate

4-[2-(7-ethoxy-[1,8]naphthyridin-4-ylamino)-4-methyl-phenylsulfanyl]-phenol

Refernces

• 1、 Barlin, Gordon B.,Tan, Weng-Lai. "Potential Antimalarials. I. 1,8-Naphthyridines". . p. 1065 - 1073. Retrieved 2007/10/02.