Glycine, N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-2-phenyl- , methyl ester, (2S)-

Base Information

Chemical Name:Glycine, N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-2-phenyl- , methyl ester, (2S)-
CAS No.:918829-64-8
Molecular Formula:C34H50N2O6Si
Molecular Weight:610.866
Hs Code.:

Glycine,
N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth
yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-2-phenyl-
, methyl ester, (2S)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Glycine, N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-2-phenyl- , methyl ester, (2S)-

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Glycine, N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-2-phenyl- , methyl ester, (2S)-

There total 5 articles about Glycine, N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-2-phenyl- , methyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 918829-63-7
(2R,4R,5R)-1-(tert-butoxycarbonyl)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-4,5-dimethylpiperidine-2-carboxylic acid

: 15028-39-4,13226-98-7
L-2-phenylglycine methyl ester hydrochloride

: 918829-64-8
tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((S)-2-methoxy-2-oxo-1-phenylethylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

Reference yield: 82.0%

: 918829-63-7
(2R,4R,5R)-1-(tert-butoxycarbonyl)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-4,5-dimethylpiperidine-2-carboxylic acid

: 6591-61-3,24461-61-8,26682-99-5,37760-98-8
(S)-Phenylglycine methyl ester

: 918829-64-8
tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((S)-2-methoxy-2-oxo-1-phenylethylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;
DOI:10.1021/jm0604878

Reference yield:

: 918829-62-6
tert-butyl (3R,4R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-3,4-dimethylpiperidine-1-carboxylate

: 918829-64-8
tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((S)-2-methoxy-2-oxo-1-phenylethylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N,N',N'-tetramethylenediamine; sec-butyllithium / diethyl ether; cyclohexane / 4.5 h / -78 °C

1.2: 73 percent / diethyl ether; cyclohexane / -78 - 20 °C

2.1: 82 percent / N,N-diisopropylethylamine; TBTU / acetonitrile / 20 °C

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In diethyl ether; cyclohexane; acetonitrile;
DOI:10.1021/jm0604878