Glycine, N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-, methyl ester

Base Information

Chemical Name:Glycine, N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-, methyl ester
CAS No.:918829-75-1
Molecular Formula:C28H46N2O6Si
Molecular Weight:534.769
Hs Code.:

Glycine,
N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth
yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-, methyl
ester

Synonyms:

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Chemical Property of Glycine, N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Glycine, N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-, methyl ester

There total 4 articles about Glycine, N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 918829-63-7
(2R,4R,5R)-1-(tert-butoxycarbonyl)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-4,5-dimethylpiperidine-2-carboxylic acid

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 918829-75-1
tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-(2-methoxy-2-oxo-1-phenylethylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

Reference yield:

: 918829-62-6
tert-butyl (3R,4R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-3,4-dimethylpiperidine-1-carboxylate

: 918829-75-1
tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-(2-methoxy-2-oxo-1-phenylethylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N,N',N'-tetramethylenediamine; sec-butyllithium / diethyl ether; cyclohexane / 4.5 h / -78 °C

1.2: 73 percent / diethyl ether; cyclohexane / -78 - 20 °C

2.1: 95 percent / N,N-diisopropylethylamine; TBTU / acetonitrile / 20 °C

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In diethyl ether; cyclohexane; acetonitrile;
DOI:10.1021/jm0604878

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 918829-75-1
tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-(2-methoxy-2-oxo-1-phenylethylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 86 percent / 4-(dimethylamino)pyridine; imidazole / dimethylformamide / 16 h / 20 °C

2.1: N,N,N',N'-tetramethylenediamine; sec-butyllithium / diethyl ether; cyclohexane / 4.5 h / -78 °C

2.2: 73 percent / diethyl ether; cyclohexane / -78 - 20 °C

3.1: 95 percent / N,N-diisopropylethylamine; TBTU / acetonitrile / 20 °C

With 1H-imidazole; dmap; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In diethyl ether; cyclohexane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0604878