3-Pyridinecarboxylic acid, 2-[(2,4-dichlorophenyl)amino]-, hydrazide

Base Information

• Chemical Name: 3-Pyridinecarboxylic acid, 2-[(2,4-dichlorophenyl)amino]-, hydrazide
• CAS No.: 918907-45-6
• Molecular Formula: C12H10Cl2N4O
• Molecular Weight: 297.14000
• Mol file: 918907-45-6.mol

Synonyms:3-Pyridinecarboxylic acid,2-[(2,4-dichlorophenyl)amino]-,hydrazide;2-(2,4-dichloroanilino)-3-pyridinecarbohydrazide;

Chemical Property of 3-Pyridinecarboxylic acid, 2-[(2,4-dichlorophenyl)amino]-, hydrazide

Chemical Property:

• PSA: 83.53000
• LogP: 4.08360

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylic acid, 2-[(2,4-dichlorophenyl)amino]-, hydrazide

There total 2 articles about 3-Pyridinecarboxylic acid, 2-[(2,4-dichlorophenyl)amino]-, hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl 2-(2,4-dichloro anilino)nicotinate (115800-79-8) → 2-(2,4-dichloroanilino)-3-pyridinecarbohydrazide (918907-45-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Heating;

DOI:10.1016/j.bmc.2006.10.027

Reference yield:

ethyl 2-chloronicotinate (1452-94-4) → 2-(2,4-dichloroanilino)-3-pyridinecarbohydrazide (918907-45-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / ethane-1,2-diol / 6 h / 160 °C

2: 80 percent / hydrazine hydrate / ethanol / 2 h / Heating

With hydrazine hydrate; In ethanol; ethylene glycol;

DOI:10.1016/j.bmc.2006.10.027

Reference yield: 75.0%

2-(2,4-dichloroanilino)-3-pyridinecarbohydrazide (918907-45-6) + 4-Fluorobenzenesulfonyl chloride (349-88-2) → C18H13Cl2FN4O3S

Guidance literature:

With pyridine; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2006.10.027

upstream raw materials:

ethyl 2-(2,4-dichloro anilino)nicotinate

ethyl 2-chloronicotinate