Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-6-O-(7-hydroxyheptyl )-N-(2-phenoxyacetyl)-, 3'-(2-propen-1-yl carbonate)

Base Information

• Chemical Name: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-6-O-(7-hydroxyheptyl )-N-(2-phenoxyacetyl)-, 3'-(2-propen-1-yl carbonate)
• CAS No.: 918947-06-5
• Molecular Formula: C50H55N5O11
• Molecular Weight: 902.014
• Mol file: 918947-06-5.mol

Synonyms:

Chemical Property of Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-6-O-(7-hydroxyheptyl )-N-(2-phenoxyacetyl)-, 3'-(2-propen-1-yl carbonate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-6-O-(7-hydroxyheptyl )-N-(2-phenoxyacetyl)-, 3'-(2-propen-1-yl carbonate)

There total 3 articles about Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-6-O-(7-hydroxyheptyl )-N-(2-phenoxyacetyl)-, 3'-(2-propen-1-yl carbonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3'-O-alloxycarbonyl-5'-O-dimethoxytrityl-N2-phenoxyacetyl-O6-(7-tert-butyldiphenylsiloxyheptyl)-2'-deoxyguanosine → 3'-O-alloxycarbonyl-5'-O-dimethoxytrityl-N2-phenoxyacetyl-O6-(7-hydroxyheptyl)-2'-deoxyguanosine (918947-06-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2006.10.074

Reference yield:

N2-phenoxyacetyl-5'-O-dimethoxytrityl-3'-O-[(allyloxy)carbonyl]-2'-deoxyguanosine → 3'-O-alloxycarbonyl-5'-O-dimethoxytrityl-N2-phenoxyacetyl-O6-(7-hydroxyheptyl)-2'-deoxyguanosine (918947-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / DIAD; triphenylphosphine

2: 100 percent / TBAF / tetrahydrofuran

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; 1: Mitsunobu reaction;

DOI:10.1016/j.tetlet.2006.10.074

Reference yield:

7-((tert-butyldiphenylsilyl)oxy)heptan-1-ol (191476-08-1) → 3'-O-alloxycarbonyl-5'-O-dimethoxytrityl-N2-phenoxyacetyl-O6-(7-hydroxyheptyl)-2'-deoxyguanosine (918947-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / DIAD; triphenylphosphine

2: 100 percent / TBAF / tetrahydrofuran

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; 1: Mitsunobu reaction;

DOI:10.1016/j.tetlet.2006.10.074

upstream raw materials:

7-((tert-butyldiphenylsilyl)oxy)heptan-1-ol

Downstream raw materials:

1-{O₆-[3'-O-alloxycarbonyl-5'-O-dimethoxytrityl-N₂-phenoxyacetyl-2'-deoxyguanidyl]}-4-{O₆-[3'-O-tertbutyldimethylsilyl-5'-O-dimethoxytrityl-N₂-phenoxyacetyl-2'-deoxyguanidyl]}-heptane