Benzenepropanoic acid, a-[[[[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]methyl](2-oxo-2-phenyleth oxy)phosphinyl]methyl]-, 2-oxo-2-phenylethyl ester

Base Information

Chemical Name:Benzenepropanoic acid, a-[[[[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]methyl](2-oxo-2-phenyleth oxy)phosphinyl]methyl]-, 2-oxo-2-phenylethyl ester
CAS No.:918949-68-5
Molecular Formula:C42H38NO8P
Molecular Weight:715.739
Hs Code.:

Benzenepropanoic acid,
a-[[[[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]methyl](2-oxo-2-phenyleth
oxy)phosphinyl]methyl]-, 2-oxo-2-phenylethyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzenepropanoic acid, a-[[[[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]methyl](2-oxo-2-phenyleth oxy)phosphinyl]methyl]-, 2-oxo-2-phenylethyl ester

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzenepropanoic acid, a-[[[[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]methyl](2-oxo-2-phenyleth oxy)phosphinyl]methyl]-, 2-oxo-2-phenylethyl ester

There total 1 articles about Benzenepropanoic acid, a-[[[[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]methyl](2-oxo-2-phenyleth oxy)phosphinyl]methyl]-, 2-oxo-2-phenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 865703-13-5
2-benzyl-3-{[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-hydroxy-phosphinoyl}-propionic acid

: 70-11-1
α-bromoacetophenone

: 918949-68-5
2-benzyl-3-[[(9H-fluoren-9-yl-methoxycarbonylamino)-methyl]-(2-oxo-2-phenyl-ethoxy)-phosphinoyl]-propionic acid 2-oxo-2-phenyl-ethyl ester

Guidance literature:: With triethylamine; In ethyl acetate; at 0 - 20 ℃;
DOI:10.1021/jo061535z

Reference yield: 62.0%

: 918949-68-5
2-benzyl-3-[[(9H-fluoren-9-yl-methoxycarbonylamino)-methyl]-(2-oxo-2-phenyl-ethoxy)-phosphinoyl]-propionic acid 2-oxo-2-phenyl-ethyl ester

: 918949-84-5
2-benzyl-3-{[(9H-fluoren-9-yl-methoxycarbonylamino)-methyl]-hydroxy-phosphinoyl}-propionic acid 2-oxo-2-phenyl-ethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 50 ℃; for 12h;
DOI:10.1021/jo061535z

Reference yield:

: 918949-68-5
2-benzyl-3-[[(9H-fluoren-9-yl-methoxycarbonylamino)-methyl]-(2-oxo-2-phenyl-ethoxy)-phosphinoyl]-propionic acid 2-oxo-2-phenyl-ethyl ester

: 3-{(adamantan-1-yloxy)-[(9H-fluoren-9-yl-methoxycarbonylamino)-methyl]-phosphinoyl}-2-benzyl-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / trifluoroacetic acid / CH₂Cl₂ / 12 h / 50 °C

2: 61 percent / Ag₂O / CHCl₃ / 12 h / Heating

3: 89 percent / acetic acid; magnesium / methanol; dimethylformamide / 4 h / 20 °C

With magnesium; acetic acid; trifluoroacetic acid; silver(l) oxide; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jo061535z