Benzenepropanoic acid, a-[[[1-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-methoxy-4-oxobutyl]( 2-oxo-2-phenylethoxy)phosphinyl]methyl]-, 2-oxo-2-phenylethyl ester

Base Information

• Chemical Name: Benzenepropanoic acid, a-[[[1-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-methoxy-4-oxobutyl]( 2-oxo-2-phenylethoxy)phosphinyl]methyl]-, 2-oxo-2-phenylethyl ester
• CAS No.: 918949-74-3
• Molecular Formula: C46H44NO10P
• Molecular Weight: 801.83
• Mol file: 918949-74-3.mol

Synonyms:

Chemical Property of Benzenepropanoic acid, a-[[[1-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-methoxy-4-oxobutyl]( 2-oxo-2-phenylethoxy)phosphinyl]methyl]-, 2-oxo-2-phenylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanoic acid, a-[[[1-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-methoxy-4-oxobutyl]( 2-oxo-2-phenylethoxy)phosphinyl]methyl]-, 2-oxo-2-phenylethyl ester

There total 1 articles about Benzenepropanoic acid, a-[[[1-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-methoxy-4-oxobutyl]( 2-oxo-2-phenylethoxy)phosphinyl]methyl]-, 2-oxo-2-phenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-[(2-carboxy-3-phenyl-propyl)-hydroxy-phosphinoyl]-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid methyl ester (865703-18-0) + α-bromoacetophenone (70-11-1) → 4-(9H-fluoren-9-yl-methoxycarbonylamino)-4-{(2-oxo-2-phenyl-ethoxy)-[2-(2-oxo-2-phenyl-ethoxycarbonyl)-3-phenyl-propyl]-phosphinoyl}-butyric acid methyl ester (918949-74-3)

Guidance literature:

With triethylamine; In ethyl acetate; at 0 - 20 ℃;

DOI:10.1021/jo061535z

Reference yield: 75.0%

4-(9H-fluoren-9-yl-methoxycarbonylamino)-4-{(2-oxo-2-phenyl-ethoxy)-[2-(2-oxo-2-phenyl-ethoxycarbonyl)-3-phenyl-propyl]-phosphinoyl}-butyric acid methyl ester (918949-74-3) → 4-(9H-fluoren-9-yl-methoxycarbonylamino)-4-{hydroxy-[2-(2-oxo-2-phenyl-ethoxycarbonyl)-3-phenyl-propyl]-phosphinoyl}-butyric acid methyl ester (918949-90-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 50 ℃; for 12h;

DOI:10.1021/jo061535z

Reference yield:

4-(9H-fluoren-9-yl-methoxycarbonylamino)-4-{(2-oxo-2-phenyl-ethoxy)-[2-(2-oxo-2-phenyl-ethoxycarbonyl)-3-phenyl-propyl]-phosphinoyl}-butyric acid methyl ester (918949-74-3) → 4-[(adamantan-1-yloxy)-(2-carboxy-3-phenyl-propyl)-phosphinoyl]-4-(9H-fluoren-9-yl-methoxycarbonylamino)-butyric acid methyl acid

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / trifluoroacetic acid / CH₂Cl₂ / 12 h / 50 °C

2: 85 percent / Ag₂O / CHCl₃ / 12 h / Heating

3: 83 percent / acetic acid; magnesium / methanol; dimethylformamide / 4 h / 20 °C

With magnesium; acetic acid; trifluoroacetic acid; silver(l) oxide; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/jo061535z

upstream raw materials:

4-[(2-carboxy-3-phenyl-propyl)-hydroxy-phosphinoyl]-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid methyl ester

α-bromoacetophenone

Downstream raw materials:

4-(9H-fluoren-9-yl-methoxycarbonylamino)-4-{hydroxy-[2-(2-oxo-2-phenyl-ethoxycarbonyl)-3-phenyl-propyl]-phosphinoyl}-butyric acid methyl ester

4-{(adamantan-1-yloxy)-[2-(2-oxo-2-phenyl-ethoxycarbonyl)-3-phenyl-propyl]-phosphinoyl}-4-(9H-fluoren-9-yl-methoxycarbonylamino)-butyric acid methyl ester