Imidazo[1,2-a]pyridine-7-methanol,2-(4-fluorophenyl)-3-[2-[[(1R)-1-phenylethyl]amino]-4-pyrimidinyl]-,7-methanesulfonate

Base Information

• Chemical Name: Imidazo[1,2-a]pyridine-7-methanol,2-(4-fluorophenyl)-3-[2-[[(1R)-1-phenylethyl]amino]-4-pyrimidinyl]-,7-methanesulfonate
• CAS No.: 918955-31-4
• Molecular Formula: C₂₇H₂₄FN₅O₃S
• Molecular Weight: 517.584
• Mol file: 918955-31-4.mol

Synonyms:

Chemical Property of Imidazo[1,2-a]pyridine-7-methanol,2-(4-fluorophenyl)-3-[2-[[(1R)-1-phenylethyl]amino]-4-pyrimidinyl]-,7-methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[1,2-a]pyridine-7-methanol,2-(4-fluorophenyl)-3-[2-[[(1R)-1-phenylethyl]amino]-4-pyrimidinyl]-,7-methanesulfonate

There total 12 articles about Imidazo[1,2-a]pyridine-7-methanol,2-(4-fluorophenyl)-3-[2-[[(1R)-1-phenylethyl]amino]-4-pyrimidinyl]-,7-methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Amino-4-methylpyridine (695-34-1) → methanesulfonic acid 2-(4-fluoro-phenyl)-3-[2-(1-phenyl-ethylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyridin-7-ylmethyl ester (918955-31-4)

Guidance literature:

Multi-step reaction with 8 steps

1: potassium permanganate

2: HCl

3: lithium aluminum hydride

4: ethanol / 60 °C

5: oxone

6: Et₃N

With hydrogenchloride; Oxone; potassium permanganate; lithium aluminium tetrahydride; triethylamine; In ethanol;

DOI:10.1016/j.bmcl.2006.08.127

Reference yield:

2-methylthio-4-methylpyrimidine (14001-63-9) → methanesulfonic acid 2-(4-fluoro-phenyl)-3-[2-(1-phenyl-ethylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyridin-7-ylmethyl ester (918955-31-4)

Guidance literature:

Multi-step reaction with 6 steps

1: lithium diisopropylamide / tetrahydrofuran

2: tetra-n-butylammonium tribromide / CH₂Cl₂

3: ethanol / 60 °C

4: oxone

5: Et₃N

With Oxone; tetra-N-butylammonium tribromide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.08.127

Reference yield:

2-acetylamino-4-methylpyridine (5327-32-2) → methanesulfonic acid 2-(4-fluoro-phenyl)-3-[2-(1-phenyl-ethylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyridin-7-ylmethyl ester (918955-31-4)

Guidance literature:

Multi-step reaction with 7 steps

1: potassium permanganate

2: HCl

3: lithium aluminum hydride

4: ethanol / 60 °C

5: oxone

6: Et₃N

With hydrogenchloride; Oxone; potassium permanganate; lithium aluminium tetrahydride; triethylamine; In ethanol;

DOI:10.1016/j.bmcl.2006.08.127

upstream raw materials:

{2-(4-fluoro-phenyl)-3-[2-(1-phenyl-ethylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyridin-7-yl}-methanol

methanesulfonyl chloride

[2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-yl]methanol

[2-(4-fluorophenyl)-3-(2-methanesulfonylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-yl]methanol