5-Oxazolidinecarboxamide, N-[(1S,2R)-2-hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]- 1-(phenylmethyl)propyl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-, (5S)-

Base Information

Chemical Name:5-Oxazolidinecarboxamide, N-[(1S,2R)-2-hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]- 1-(phenylmethyl)propyl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-, (5S)-
CAS No.:919081-36-0
Molecular Formula:C31H33F3N4O8S
Molecular Weight:678.686
Hs Code.:

5-Oxazolidinecarboxamide,
N-[(1S,2R)-2-hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-
1-(phenylmethyl)propyl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-, (5S)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Oxazolidinecarboxamide, N-[(1S,2R)-2-hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]- 1-(phenylmethyl)propyl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-, (5S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Oxazolidinecarboxamide, N-[(1S,2R)-2-hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]- 1-(phenylmethyl)propyl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-, (5S)-

There total 8 articles about 5-Oxazolidinecarboxamide, N-[(1S,2R)-2-hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]- 1-(phenylmethyl)propyl]-2-oxo-3-[3-(trifluoromethyl)phenyl]-, (5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18585-04-1
(3-trifluoromethyl-phenyl)-carbamic acid benzyl ester

: 919081-36-0
2-oxo-3-(3-trifluoromethyl-phenyl)-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.75 h / -78 °C

1.2: tetrahydrofuran; hexane / -78 - 20 °C

2.1: NaIO₄ / RuCl₃*H₂O / acetonitrile; CCl₄ / 0 - 20 °C

3.1: oxalyl chloride / 20 °C

4.1: Et₃N / tetrahydrofuran / 20 °C

With sodium periodate; n-butyllithium; oxalyl dichloride; triethylamine; ruthenium trichloride; In tetrahydrofuran; tetrachloromethane; hexane; acetonitrile;
DOI:10.1021/jm060666p

Reference yield:

: 919081-44-0
(S)-5-(hydroxymethyl)-3-(3-trifluoromethylphenyl)oxazolidin-2-one

: 919081-36-0
2-oxo-3-(3-trifluoromethyl-phenyl)-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1: NaIO₄ / RuCl₃*H₂O / acetonitrile; CCl₄ / 0 - 20 °C

2: oxalyl chloride / 20 °C

3: Et₃N / tetrahydrofuran / 20 °C

With sodium periodate; oxalyl dichloride; triethylamine; ruthenium trichloride; In tetrahydrofuran; tetrachloromethane; acetonitrile;
DOI:10.1021/jm060666p

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 919081-36-0
2-oxo-3-(3-trifluoromethyl-phenyl)-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaHCO₃ / acetone; H₂O / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.75 h / -78 °C

2.2: tetrahydrofuran; hexane / -78 - 20 °C

3.1: NaIO₄ / RuCl₃*H₂O / acetonitrile; CCl₄ / 0 - 20 °C

4.1: oxalyl chloride / 20 °C

5.1: Et₃N / tetrahydrofuran / 20 °C

With sodium periodate; n-butyllithium; oxalyl dichloride; sodium hydrogencarbonate; triethylamine; ruthenium trichloride; In tetrahydrofuran; tetrachloromethane; hexane; water; acetone; acetonitrile;
DOI:10.1021/jm060666p