(5S)-5-(Hydroxymethyl)-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidin-2-one

Base Information

Chemical Name:(5S)-5-(Hydroxymethyl)-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidin-2-one
CAS No.:919081-44-0
Molecular Formula:C11H10F3NO3
Molecular Weight:261.201
Hs Code.:
DSSTox Substance ID:DTXSID70582383
Wikidata:Q82473795

Synonyms:919081-44-0;(5S)-5-(Hydroxymethyl)-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidin-2-one;DTXSID70582383

Suppliers and Price of (5S)-5-(Hydroxymethyl)-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of (5S)-5-(Hydroxymethyl)-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidin-2-one

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:261.06127767
Heavy Atom Count:18
Complexity:321

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(OC(=O)N1C2=CC=CC(=C2)C(F)(F)F)CO
Isomeric SMILES:C1[C@H](OC(=O)N1C2=CC=CC(=C2)C(F)(F)F)CO

Technology Process of (5S)-5-(Hydroxymethyl)-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidin-2-one

There total 2 articles about (5S)-5-(Hydroxymethyl)-3-[3-(trifluoromethyl)phenyl]-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18585-04-1
(3-trifluoromethyl-phenyl)-carbamic acid benzyl ester

: 65031-96-1
(S)-glycidyl butyrate

: 919081-44-0
(S)-5-(hydroxymethyl)-3-(3-trifluoromethylphenyl)oxazolidin-2-one

Guidance literature:: (3-trifluoromethyl-phenyl)-carbamic acid benzyl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h;

(S)-glycidyl butyrate; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1021/jm060666p

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 919081-44-0
(S)-5-(hydroxymethyl)-3-(3-trifluoromethylphenyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaHCO₃ / acetone; H₂O / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.75 h / -78 °C

2.2: tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; sodium hydrogencarbonate; In tetrahydrofuran; hexane; water; acetone;
DOI:10.1021/jm060666p