6-Phenyl-2-(3-phenyl-2-aziridinyl)-3-oxa-1-azabicyclo[3.1.0]hexan-4-ol

Base Information

Chemical Name:6-Phenyl-2-(3-phenyl-2-aziridinyl)-3-oxa-1-azabicyclo[3.1.0]hexan-4-ol
CAS No.:919101-04-5
Molecular Formula:C₁₈H₁₈N₂O₂
Molecular Weight:294.353
Hs Code.:
Mol file:919101-04-5.mol

Synonyms:3-Oxa-1-azabicyclo[3.1.0]hexan-4-ol,6-phenyl-2-[(2R,3S)-3-phenyl-2-aziridinyl]-,(2R,4R,5S,6R)-rel;

Suppliers and Price of 6-Phenyl-2-(3-phenyl-2-aziridinyl)-3-oxa-1-azabicyclo[3.1.0]hexan-4-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
3-Phenylaziridine-2-carboxaldehyde dimer
1g
$ 163.00

Sigma-Aldrich
3-Phenylaziridine-2-carboxaldehyde dimer
250mg
$ 62.80

American Custom Chemicals Corporation
3-PHENYLAZIRIDINE-2-CARBOXALDEHYDE DIMER 95.00%
5MG
$ 499.05

Total 6 raw suppliers

Chemical Property of 6-Phenyl-2-(3-phenyl-2-aziridinyl)-3-oxa-1-azabicyclo[3.1.0]hexan-4-ol

Chemical Property:

Melting Point:132-136oC
PSA：54.41000
LogP:2.06640

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Phenylaziridine-2-carboxaldehyde dimer ^*data from reagent suppliers

Safty Information:

Pictogram(s): F,Xi
Hazard Codes:F,Xi
Statements: 11-37/38-41-42/43
Safety Statements: 22-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 6-Phenyl-2-(3-phenyl-2-aziridinyl)-3-oxa-1-azabicyclo[3.1.0]hexan-4-ol

There total 3 articles about 6-Phenyl-2-(3-phenyl-2-aziridinyl)-3-oxa-1-azabicyclo[3.1.0]hexan-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 912646-63-0
(2S,3R)-ethyl 3-phenylaziridine-2-carboxylate

: 919101-04-5
6-phenyl-2-(3-phenylaziridin-2-yl)-3-oxa-1-azabicyclo[3.1.0]hexan-4-ol

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 1h;

Reference yield: 83.0%

: 84024-60-2,84024-61-3
trans-3-phenylaziridine-2-carboxylic acid ethyl ester

: 919101-04-5
6-phenyl-2-(3-phenylaziridin-2-yl)-3-oxa-1-azabicyclo[3.1.0]hexan-4-ol

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 1h;
DOI:10.1021/ja065898s

Reference yield:

: 121-39-1
ethyl 3-phenylglycidate

: 919101-04-5
6-phenyl-2-(3-phenylaziridin-2-yl)-3-oxa-1-azabicyclo[3.1.0]hexan-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaN₃; ammonium chloride / ethanol / 5 h / 65 °C

1.2: 61 percent / PPh₃ / acetonitrile / 5 h / 83 °C

2.1: 83 percent / DIBAL / toluene / 1 h / -78 °C

With sodium azide; ammonium chloride; diisobutylaluminium hydride; In ethanol; toluene;
DOI:10.1021/ja065898s