912646-63-0Relevant academic research and scientific papers
COVALENT RAS INHIBITORS AND USES THEREOF
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Page/Page column 152; 153, (2021/06/04)
The disclosure features compounds, or pharmaceutically acceptable salts thereof, alone and in combination with other therapeutic agents, pharmaceutical compositions, and protein conjugates thereof, capable of modulating biological processes including Ras, and their uses in the treatment of cancers.
RAS INHIBITORS
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Paragraph 1294; 1298, (2021/05/07)
The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
AZIRIDINE ALDEHYDES, AZIRIDINE-CONJUGATED AMMO DERIVATIVES, AZIRIDINE-CONJUGATED BIOMOLECULES AND PROCESSES FOR THEIR PREPARATION
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Page/Page column 69, (2008/12/05)
The present invention relates to unprotected amino aldehydes and applications for same. More particularly, the present invention relates to novel aziridine aldehydes and processes for preparing these novel compounds. The invention also relates to aziridine-conjugated amino derivatives, and processes for preparing the same. Pentacyclic compounds may be prepared using the aziridine aldehydes of the present invention, and the invention relates to these compounds and the processes by which they are made. The invention also relates to aziridine-conjugated bioactive molecules, such as amino acids and peptides, and processes for preparing such compounds.
Stereoselective synthesis of N-alkylaziridines from N-chloroamines
Bew, Sean P.,Hughes,Palmer, Nicholas J.,Savic, Vladimir,Soapi, Katy M.,Wilson, Martin A.
, p. 4338 - 4340 (2007/10/03)
We report the first racemic and stereoselective synthesis of cis- and trans-N-alkylaziridines via N-chloroamines; using this methodology an N-3,4,5-trimethoxybenzylaziridine was synthesised and efficiently cleaved, affording the corresponding NH aziridine
