3(2H)-Pyridazinone,6-[4-[[(2S)-4-[[3-chloro-1-(phenylsulfonyl)-1H-indol-6-yl]sulfonyl]-2-methyl-6-oxo-1-piperazinyl]methyl]phenyl]-2-methyl-

Base Information

Chemical Name:3(2H)-Pyridazinone,6-[4-[[(2S)-4-[[3-chloro-1-(phenylsulfonyl)-1H-indol-6-yl]sulfonyl]-2-methyl-6-oxo-1-piperazinyl]methyl]phenyl]-2-methyl-
CAS No.:919110-12-6
Molecular Formula:C31H28ClN5O6S2
Molecular Weight:666.178
Hs Code.:

3(2H)-Pyridazinone,6-[4-[[(2S)-4-[[3-chloro-1-(phenylsulfonyl)-1H-indol-6-yl]sulfonyl]-2-methyl-6-oxo-1-piperazinyl]methyl]phenyl]-2-methyl-

Synonyms:

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Chemical Property of 3(2H)-Pyridazinone,6-[4-[[(2S)-4-[[3-chloro-1-(phenylsulfonyl)-1H-indol-6-yl]sulfonyl]-2-methyl-6-oxo-1-piperazinyl]methyl]phenyl]-2-methyl-

Chemical Property:

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3(2H)-Pyridazinone,6-[4-[[(2S)-4-[[3-chloro-1-(phenylsulfonyl)-1H-indol-6-yl]sulfonyl]-2-methyl-6-oxo-1-piperazinyl]methyl]phenyl]-2-methyl-

There total 7 articles about 3(2H)-Pyridazinone,6-[4-[[(2S)-4-[[3-chloro-1-(phenylsulfonyl)-1H-indol-6-yl]sulfonyl]-2-methyl-6-oxo-1-piperazinyl]methyl]phenyl]-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 919110-11-5
2-methyl-6-[4-((S)-2-methyl-6-oxopiperazin-1-ylmethyl)-phenyl]-2H-pyridazin-3-one

: 919110-32-0
1-benzenesulfonyl-3-chloro-1H-indole-6-sulfonyl chloride

: 919110-12-6
6-(4-(S)-(4-(1-benzenesulfonyl-3-chloro-1H-indole-6-sulfonyl)-2-methyl-6-oxopiperazin-1-ylmethyl)-phenyl)-2-methyl-2H-pyridazin-3-one

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

Reference yield:

: 87199-17-5
4-formylphenylboronic acid,

: 919110-12-6
6-(4-(S)-(4-(1-benzenesulfonyl-3-chloro-1H-indole-6-sulfonyl)-2-methyl-6-oxopiperazin-1-ylmethyl)-phenyl)-2-methyl-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / trans benzyl(chloro)bis(triphenylphosphine)palladium(II) / 1,2-dimethoxyethane; ethanol; water / 0.17 h / 150 °C

2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 20 °C

3: triethylamine / 2 h / 0 - 20 °C

4: hydrogenchloride / methanol / 1 h / 0 - 20 °C

5: triethylamine / N,N-dimethyl-formamide / 48 h / 0 - 20 °C

6: triethylamine / dichloromethane / 4 h / 0 - 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; triethylamine; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 10071-38-2
6-Chloro-2-methyl-2H-pyridazin-3-one

: 919110-12-6
6-(4-(S)-(4-(1-benzenesulfonyl-3-chloro-1H-indole-6-sulfonyl)-2-methyl-6-oxopiperazin-1-ylmethyl)-phenyl)-2-methyl-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / trans benzyl(chloro)bis(triphenylphosphine)palladium(II) / 1,2-dimethoxyethane; ethanol; water / 0.17 h / 150 °C

2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 20 °C

3: triethylamine / 2 h / 0 - 20 °C

4: hydrogenchloride / methanol / 1 h / 0 - 20 °C

5: triethylamine / N,N-dimethyl-formamide / 48 h / 0 - 20 °C

6: triethylamine / dichloromethane / 4 h / 0 - 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; triethylamine; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;