4-Pyrimidinamine, 2-chloro-N-(3-chloro-4-fluorophenyl)-

Base Information

• Chemical Name: 4-Pyrimidinamine, 2-chloro-N-(3-chloro-4-fluorophenyl)-
• CAS No.: 919200-71-8
• Molecular Formula: C10H6Cl2FN3
• Molecular Weight: 258.082

Synonyms:(2-chloropyrimidin-4-yl)(3-chloro-4-fluorophenyl)amine;4-Pyrimidinamine,2-chloro-N-(3-chloro-4-fluorophenyl);

Chemical Property of 4-Pyrimidinamine, 2-chloro-N-(3-chloro-4-fluorophenyl)-

Chemical Property:

• PSA: 41.04000
• LogP: 3.08800

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyrimidinamine, 2-chloro-N-(3-chloro-4-fluorophenyl)-

There total 2 articles about 4-Pyrimidinamine, 2-chloro-N-(3-chloro-4-fluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.2%

2,6-Dichloropyrimidine (3934-20-1) + 3-chloro-4-fluorophenylamine (367-21-5) → 2-chloro-4-(3-chloro-4-fluoroaniline)pyrimidine (919200-71-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; for 18h; Heating / reflux;

Reference yield:

2,6-Dichloropyrimidine (3934-20-1) + 3-chloro-4-fluorophenylamine (367-21-5) + diisopropylethyl amine (DIPEA) → 2-chloro-4-(3-chloro-4-fluoroaniline)pyrimidine (919200-71-8)

Guidance literature:

In hexane; dichloromethane; ethyl acetate; isopropyl alcohol;

Reference yield: 90.0%

6-(4-methyl-1-piperazinyl)-3-pyridinylamine (55403-35-5) + 2-chloro-4-(3-chloro-4-fluoroaniline)pyrimidine (919200-71-8) + 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran (96042-30-7) → N4-(3-chloro-4-fluorophenyl)-N2-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)pyrimidine-2,4-diamine (1050499-94-9)

Guidance literature:

With sodium hydroxide; trifluoroacetic acid; In methanol; isopropyl alcohol;

upstream raw materials:

2,6-Dichloropyrimidine

3-chloro-4-fluorophenylamine

Downstream raw materials:

N₄-(3-chloro-4-fluorophenyl)-N₂-(4-morpholinophenyl)pyrimidine-2,4-diamine

N₄-(3-chloro-4-fluorophenyl)-N₂-(4-(4-methylpiperazin-1-yl)phenyl)pyrimidine-2,4-diamine

N₄-(3-chloro-4-fluorophenyl)-N₂-(4-fluorophenyl)pyrimidine-2,4-diamine

N₄-(3-chloro-4-fluorophenyl)-N₂-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)pyrimidine-2,4-diamine

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