Methyl 3-amino-2,4-bis(methoxymethoxy)benzoate

Base Information

Chemical Name:Methyl 3-amino-2,4-bis(methoxymethoxy)benzoate
CAS No.:919286-02-5
Molecular Formula:C12H17NO6
Molecular Weight:271.27
Hs Code.:
DSSTox Substance ID:DTXSID20475599
Nikkaji Number:J2.387.204H
Wikidata:Q82306229

Synonyms:Methyl 3-amino-2,4-bis(methoxymethoxy)benzoate;919286-02-5;SCHEMBL15096303;DTXSID20475599

Suppliers and Price of Methyl 3-amino-2,4-bis(methoxymethoxy)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 3-amino-2,4-bis(methoxymethoxy)benzoate

Chemical Property:

PSA：89.24000
LogP:1.60200
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:271.10558726
Heavy Atom Count:19
Complexity:275

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COCOC1=C(C(=C(C=C1)C(=O)OC)OCOC)N

Technology Process of Methyl 3-amino-2,4-bis(methoxymethoxy)benzoate

There total 7 articles about Methyl 3-amino-2,4-bis(methoxymethoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 956105-76-3
methyl 2,4-bis(methoxymethoxy)-3-nitrobenzoate

: 919286-02-5
methyl 3-amino-2,4-bis(methoxymethoxy)benzoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 16h;
DOI:10.1055/s-2007-983843

Reference yield: 83.0%

: 919286-18-3
3-tert-butoxycarbonylamino-2,4-bis-methoxymethoxy-benzoic acid methyl ester

: 919286-02-5
methyl 3-amino-2,4-bis(methoxymethoxy)benzoate

Guidance literature:: In 1,2-dichloro-benzene; at 205 ℃; for 0.0833333h; microwave irradiation;
DOI:10.1002/anie.200603892

Reference yield:

: 601-89-8
2-nitroresorcinol

: 919286-02-5
methyl 3-amino-2,4-bis(methoxymethoxy)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 82 percent / NaH / tetrahydrofuran / 1.5 h / 0 - 22 °C

2.1: 99 percent / H₂ / Pd/C / methanol; ethyl acetate / 12 h / 22 °C

3.1: 99 percent / 4 h / 40 °C

4.1: n-BuLi; TMSCl / pentane / 0.25 h / -78 °C

4.2: n-BuLi / pentane; tetrahydrofuran / 0.5 h / -78 °C

4.3: 54 percent / aq. HCl / 0.5 h / 22 °C

5.1: 83 percent / 1,2-dichloro-benzene / 0.08 h / 205 °C / microwave irradiation

With n-butyllithium; chloro-trimethyl-silane; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; 1,2-dichloro-benzene; pentane;
DOI:10.1002/anie.200603892