Technology Process of Benzoic acid,
3-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4-bis(methoxymethoxy)-,
methyl ester
There total 4 articles about Benzoic acid,
3-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4-bis(methoxymethoxy)-,
methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2,6-bis-methoxymethoxy-phenyl)-carbamic acid tert-butyl ester;
With
n-butyllithium; chloro-trimethyl-silane;
In
pentane;
at -78 ℃;
for 0.25h;
methyl cyanoformate;
With
n-butyllithium;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 0.5h;
With
hydrogenchloride;
at 22 ℃;
for 0.5h;
DOI:10.1002/anie.200603892
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 82 percent / NaH / tetrahydrofuran / 1.5 h / 0 - 22 °C
2.1: 99 percent / H2 / Pd/C / methanol; ethyl acetate / 12 h / 22 °C
3.1: 99 percent / 4 h / 40 °C
4.1: n-BuLi; TMSCl / pentane / 0.25 h / -78 °C
4.2: n-BuLi / pentane; tetrahydrofuran / 0.5 h / -78 °C
4.3: 54 percent / aq. HCl / 0.5 h / 22 °C
With
n-butyllithium; chloro-trimethyl-silane; hydrogen; sodium hydride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethyl acetate; pentane;
DOI:10.1002/anie.200603892
- Guidance literature:
-
C18H31NO6Si;
With
n-butyllithium;
In
tetrahydrofuran; pentane;
at -78 - 0 ℃;
Inert atmosphere;
methyl cyanoformate;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1021/ja9068003
