4-(3-Hydroxy-1-Methylpropyl)-1-piperidinecarboxylic Acid 1,1-DiMethylethyl Ester

Base Information

• Chemical Name: 4-(3-Hydroxy-1-Methylpropyl)-1-piperidinecarboxylic Acid 1,1-DiMethylethyl Ester
• CAS No.: 919360-49-9
• Molecular Formula: C₁₄H₂₇NO₃
• Molecular Weight: 257.373
• Mol file: 919360-49-9.mol

Synonyms:

Chemical Property of 4-(3-Hydroxy-1-Methylpropyl)-1-piperidinecarboxylic Acid 1,1-DiMethylethyl Ester

Chemical Property:

• Boiling Point: 349.7±15.0 °C(Predicted)
• PKA: 15.10±0.10(Predicted)
• PSA: 0.00000
• Density: 1.026±0.06 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

4-(3-Hydroxy-1-methylpropyl)-1-piperidinecarboxylicAcid1,1-DimethylethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(3-Hydroxy-1-methylpropyl)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester is used in the synthesis of GPR119 agonists in the treatment of diabetes and obesity.

Technology Process of 4-(3-Hydroxy-1-Methylpropyl)-1-piperidinecarboxylic Acid 1,1-DiMethylethyl Ester

There total 1 articles about 4-(3-Hydroxy-1-Methylpropyl)-1-piperidinecarboxylic Acid 1,1-DiMethylethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-ethoxycarbonyl-1-methylethyl)piperidine-1-carboxylic acid tert-butyl ester (203662-40-2) → 4-(3-hydroxy-1-methylpropyl)piperidine-1-carboxylic acid tert-butyl ester (919360-49-9)

Guidance literature:

4-(2-ethoxycarbonyl-1-methylethyl)piperidine-1-carboxylic acid tert-butyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With sodium hydroxide; water; In tetrahydrofuran;

upstream raw materials:

4-(2-ethoxycarbonyl-1-methylethyl)piperidine-1-carboxylic acid tert-butyl ester

Refernces