4-Piperidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-b-methyl-, ethyl ester

Base Information

• Chemical Name: 4-Piperidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-b-methyl-, ethyl ester
• CAS No.: 203662-40-2
• Molecular Formula: C16H29NO4
• Molecular Weight: 299.40600
• Mol file: 203662-40-2.mol

Synonyms:

Chemical Property of 4-Piperidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-b-methyl-, ethyl ester

Chemical Property:

• PSA: 55.84000
• LogP: 3.16070

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl4-(4-ethoxy-4-oxobutan-2-yl)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Piperidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-b-methyl-, ethyl ester

There total 1 articles about 4-Piperidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-b-methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-acetyl-1-(t-butoxycarbonyl)piperidine (206989-61-9) → 4-(2-ethoxycarbonyl-1-methylethyl)piperidine-1-carboxylic acid tert-butyl ester (203662-40-2)

Guidance literature:

Reference yield:

4-(2-ethoxycarbonyl-1-methylethyl)piperidine-1-carboxylic acid tert-butyl ester (203662-40-2) → 4-{2-[3-(3-fluoro-4-methylsulfanylphenyl)-[1,2,4]oxadiazol-5-yl]-1-methyl-ethyl}piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:

3-fluoro-N-hydroxy-4-methylsulfanylbenzamidine; With sodium hydride; In tetrahydrofuran; for 0.666667h;

4-(2-ethoxycarbonyl-1-methylethyl)piperidine-1-carboxylic acid tert-butyl ester; In tetrahydrofuran; for 18h; Heating / reflux;

Reference yield:

4-(2-ethoxycarbonyl-1-methylethyl)piperidine-1-carboxylic acid tert-butyl ester (203662-40-2) → 4-(3-hydroxy-1-methylpropyl)piperidine-1-carboxylic acid tert-butyl ester (919360-49-9)

Guidance literature:

4-(2-ethoxycarbonyl-1-methylethyl)piperidine-1-carboxylic acid tert-butyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With sodium hydroxide; water; In tetrahydrofuran;

upstream raw materials:

4-acetyl-1-(t-butoxycarbonyl)piperidine

Downstream raw materials:

4-(3-hydroxy-1-methylpropyl)piperidine-1-carboxylic acid tert-butyl ester

Refernces