(3R)-5-oxo-3-Pyrrolidinecarboxylic acid ethyl ester

Base Information

• Chemical Name: (3R)-5-oxo-3-Pyrrolidinecarboxylic acid ethyl ester
• CAS No.: 919513-66-9
• Molecular Formula: C₇H₁₁NO₃
• Molecular Weight: 157.169
• Mol file: 919513-66-9.mol

Synonyms:

Chemical Property of (3R)-5-oxo-3-Pyrrolidinecarboxylic acid ethyl ester

Chemical Property:

• Boiling Point: 312.7±35.0 °C(Predicted)
• PKA: 15.39±0.40(Predicted)
• PSA: 55.40000
• Density: 1.161±0.06 g/cm3(Predicted)
• LogP: 0.01440

Purity/Quality:

(3R)-5-oxo-3-Pyrrolidinecarboxylicacidethylester 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (3R)-5-oxo-3-Pyrrolidinecarboxylic acid ethyl ester

There total 7 articles about (3R)-5-oxo-3-Pyrrolidinecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-ethyl-4-(4-methoxyphenyl)-4-oxobut-2-enoate (127427-28-5) → ethyl (R)-5-oxopyrrolidine-3-carboxylate (919513-66-9)

Guidance literature:

Multi-step reaction with 3 steps

1: C₂₉H₂₈F₆N₄OS / 5,5-dimethyl-1,3-cyclohexadiene / 14 h / 25 °C

2: trifluorormethanesulfonic acid; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 21 h / 20 °C / Inert atmosphere

3: sodium tetrahydroborate; nickel (II) chloride hexahydrate / ethanol

With sodium tetrahydroborate; nickel (II) chloride hexahydrate; trifluorormethanesulfonic acid; C₂₉H₂₈F₆N₄OS; 3-chloro-benzenecarboperoxoic acid; In 5,5-dimethyl-1,3-cyclohexadiene; ethanol; dichloromethane; 1: Michael addition / 2: Baeyer-Villiger oxidation;

DOI:10.1039/b905033g

Reference yield:

ethyl (R)-4-(4-methoxyphenyl)-2-(nitromethyl)-4-oxobutanoate (1185984-75-1) → ethyl (R)-5-oxopyrrolidine-3-carboxylate (919513-66-9)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluorormethanesulfonic acid; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 21 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate; nickel (II) chloride hexahydrate / ethanol

With sodium tetrahydroborate; nickel (II) chloride hexahydrate; trifluorormethanesulfonic acid; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; 1: Baeyer-Villiger oxidation;

DOI:10.1039/b905033g

Reference yield:

1-ethyl 4-(4-methoxyphenyl) (R)-2-(nitromethyl)succinate (1185985-44-7) → ethyl (R)-5-oxopyrrolidine-3-carboxylate (919513-66-9)

Guidance literature:

With sodium tetrahydroborate; nickel (II) chloride hexahydrate; In ethanol;

DOI:10.1039/b905033g

upstream raw materials:

trans-ethyl-4-(4-methoxyphenyl)-4-oxobut-2-enoate

ethyl (R)-4-(4-methoxyphenyl)-2-(nitromethyl)-4-oxobutanoate

1-ethyl 4-(4-methoxyphenyl) (R)-2-(nitromethyl)succinate

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