Ethanone, 1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-2-[[2-(2-iodophenyl)eth yl]methylamino]-2-phenyl-

Base Information

• Chemical Name: Ethanone, 1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-2-[[2-(2-iodophenyl)eth yl]methylamino]-2-phenyl-
• CAS No.: 919519-07-6
• Molecular Formula: C29H36INO2Si
• Molecular Weight: 585.6
• Mol file: 919519-07-6.mol

Synonyms:

Chemical Property of Ethanone, 1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-2-[[2-(2-iodophenyl)eth yl]methylamino]-2-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-2-[[2-(2-iodophenyl)eth yl]methylamino]-2-phenyl-

There total 4 articles about Ethanone, 1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-2-[[2-(2-iodophenyl)eth yl]methylamino]-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.3%

N-methyl-2-(2-iodophenyl)ethylamine (881538-16-5) + 4(t-butyldimethylsilyloxy)-α-phenylphenacyl bromide (191536-17-1) → 4-t-butyldimethylsilyloxy-N-[2-(2-iodophenyl)ethyl]-N-methyl-α-phenylphenacylamine (919519-07-6)

Guidance literature:

With methyloxirane; In 1,4-dioxane; at 110 ℃; for 1.5h;

DOI:10.3987/com-06-10853

Reference yield:

1-(4-((tert-butyldimethylsilyl)oxy)phenyl)-2-phenylethan-1-one (163083-22-5) → 4-t-butyldimethylsilyloxy-N-[2-(2-iodophenyl)ethyl]-N-methyl-α-phenylphenacylamine (919519-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 43.3 percent / benzyltrimethyl-ammonium tribromide / CH₂Cl₂; methanol / 5 h / Heating

2: 83.3 percent / propylene oxide / dioxane / 1.5 h / 110 °C

With benzyltrimethylammonium tribromide; methyloxirane; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.3987/com-06-10853

Reference yield:

1-(4-Hydroxyphenyl)-2-phenylethanone (2491-32-9) → 4-t-butyldimethylsilyloxy-N-[2-(2-iodophenyl)ethyl]-N-methyl-α-phenylphenacylamine (919519-07-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 96.4 percent / imidazole / CH₂Cl₂ / 2 h / 20 °C

2: 43.3 percent / benzyltrimethyl-ammonium tribromide / CH₂Cl₂; methanol / 5 h / Heating

3: 83.3 percent / propylene oxide / dioxane / 1.5 h / 110 °C

With 1H-imidazole; benzyltrimethylammonium tribromide; methyloxirane; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.3987/com-06-10853

upstream raw materials:

N-methyl-2-(2-iodophenyl)ethylamine

4(t-butyldimethylsilyloxy)-α-phenylphenacyl bromide

1-(4-((tert-butyldimethylsilyl)oxy)phenyl)-2-phenylethan-1-one

1-(4-Hydroxyphenyl)-2-phenylethanone

Downstream raw materials:

1-hydroxy-1-(4-hydroxyphenyl)-3-methyl-2-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

1-[4-(t-butyldimethylsilyloxy)phenyl]-1-hydroxy-3-methyl-2-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Refernces