1-[4-(t-butyldimethylsilyloxy)phenyl]-1-hydroxy-3-methyl-2-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:1-[4-(t-butyldimethylsilyloxy)phenyl]-1-hydroxy-3-methyl-2-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:919519-17-8
Molecular Formula:C₂₉H₃₇NO₂Si
Molecular Weight:459.704
Hs Code.:

Synonyms:1-[4-(t-butyldimethylsilyloxy)phenyl]-1-hydroxy-3-methyl-2-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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Chemical Property of 1-[4-(t-butyldimethylsilyloxy)phenyl]-1-hydroxy-3-methyl-2-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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Technology Process of 1-[4-(t-butyldimethylsilyloxy)phenyl]-1-hydroxy-3-methyl-2-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 5 articles about 1-[4-(t-butyldimethylsilyloxy)phenyl]-1-hydroxy-3-methyl-2-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 919519-07-6
4-t-butyldimethylsilyloxy-N-[2-(2-iodophenyl)ethyl]-N-methyl-α-phenylphenacylamine

: 919519-17-8
1-[4-(t-butyldimethylsilyloxy)phenyl]-1-hydroxy-3-methyl-2-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 0.5h;
DOI:10.3987/com-06-10853

Reference yield:

: 163083-22-5
1-(4-((tert-butyldimethylsilyl)oxy)phenyl)-2-phenylethan-1-one

: 919519-17-8
1-[4-(t-butyldimethylsilyloxy)phenyl]-1-hydroxy-3-methyl-2-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 43.3 percent / benzyltrimethyl-ammonium tribromide / CH₂Cl₂; methanol / 5 h / Heating

2: 83.3 percent / propylene oxide / dioxane / 1.5 h / 110 °C

3: 50 percent / n-C₄H₉Li / hexane; tetrahydrofuran / 0.5 h / 20 °C

With n-butyllithium; benzyltrimethylammonium tribromide; methyloxirane; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; 3: intramolecular Barbier reaction;
DOI:10.3987/com-06-10853

Reference yield:

: 2491-32-9
1-(4-Hydroxyphenyl)-2-phenylethanone

: 919519-17-8
1-[4-(t-butyldimethylsilyloxy)phenyl]-1-hydroxy-3-methyl-2-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 96.4 percent / imidazole / CH₂Cl₂ / 2 h / 20 °C

2: 43.3 percent / benzyltrimethyl-ammonium tribromide / CH₂Cl₂; methanol / 5 h / Heating

3: 83.3 percent / propylene oxide / dioxane / 1.5 h / 110 °C

4: 50 percent / n-C₄H₉Li / hexane; tetrahydrofuran / 0.5 h / 20 °C

With 1H-imidazole; n-butyllithium; benzyltrimethylammonium tribromide; methyloxirane; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; 4: intramolecular Barbier reaction;
DOI:10.3987/com-06-10853