1-Naphthylamine, 5-methoxy-1,2,3,4-tetrahydro-, hydrochloride

Base Information

• Chemical Name: 1-Naphthylamine, 5-methoxy-1,2,3,4-tetrahydro-, hydrochloride
• CAS No.: 41566-70-5
• Molecular Formula: C₁₁H₁₅NO*ClH
• Molecular Weight: 213.707
• Hs Code.: 2922299090
• Mol file: 41566-70-5.mol

Synonyms:1-Naphthylamine, 5-methoxy-1,2,3,4-tetrahydro-, hydrochloride;(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)azanium;chloride;1-NAPHTHYLAMINE, 1,2,3,4-TETRAHYDRO-5-METHOXY-, HYDROCHLORIDE;SCHEMBL3147319;LS-95835

Chemical Property of 1-Naphthylamine, 5-methoxy-1,2,3,4-tetrahydro-, hydrochloride

Chemical Property:

• Vapor Pressure: 0.0013mmHg at 25°C
• Boiling Point: 298.1°Cat760mmHg
• Flash Point: 138.5°C
• PSA: 35.25000
• Density: g/cm³
• LogP: 3.53360
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 213.0920418
• Heavy Atom Count: 14
• Complexity: 172

Purity/Quality:

99% ^*data from raw suppliers

5-Methoxy-1,2,3,4-tetrahydronaphthalen-1-aminehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1CCCC2[NH3+].[Cl-]

Technology Process of 1-Naphthylamine, 5-methoxy-1,2,3,4-tetrahydro-, hydrochloride

There total 5 articles about 1-Naphthylamine, 5-methoxy-1,2,3,4-tetrahydro-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-azido-5-methoxy-1,2,3,4-tetrahydronaphthalene (187994-46-3) → 1-amino-5-methoxy-1,2,3,4-tetrahydronaphthalene hydrochloride (41566-70-5)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; chloroform; at 25 ℃; for 20h;

DOI:10.3109/14756366.2012.750311

Reference yield: 79.0%

NaBH3 CN + NH4 OAc + 5-Methoxy-1-tetralone (33892-75-0) → 1-amino-5-methoxy-1,2,3,4-tetrahydronaphthalene hydrochloride (41566-70-5)

Guidance literature:

In methanol; water;

Reference yield:

5-Methoxy-1-tetralone (33892-75-0) → 1-amino-5-methoxy-1,2,3,4-tetrahydronaphthalene hydrochloride (41566-70-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol / 3 h / 0 - 25 °C

2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 14 h / 0 - 25 °C / Inert atmosphere

3: palladium on activated charcoal; hydrogen / methanol; chloroform / 20 h / 25 °C

With sodium tetrahydroborate; diphenyl phosphoryl azide; palladium on activated charcoal; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; chloroform;

DOI:10.3109/14756366.2012.750311

upstream raw materials:

5-Methoxy-1-tetralone

1-azido-5-methoxy-1,2,3,4-tetrahydronaphthalene

1,2,3,4-tetrahydro-5-methoxynaphthalen-1-ol

Refernces

• 1、 -. "Substituted amino-5,6,7,8-tetrahydronaphthyl-oxyacetic acids, processes for their preparation and their use as medicaments". . . Retrieved 2008/06/13.