1-((3-(4-Methoxyphenyl)-1,2,4-triazolo(3,4-a)phthalazin-6-yl)methylamino)-2-propanol

Base Information

Chemical Name:1-((3-(4-Methoxyphenyl)-1,2,4-triazolo(3,4-a)phthalazin-6-yl)methylamino)-2-propanol
CAS No.:87539-86-4
Molecular Formula:C20H21N5O2
Molecular Weight:363.413
Hs Code.:
DSSTox Substance ID:DTXSID801007619
ChEMBL ID:CHEMBL14214

Synonyms:BRN 6439548;1-((3-(4-Methoxyphenyl)-1,2,4-triazolo(3,4-a)phthalazin-6-yl)methylamino)-2-propanol;2-Propanol, 1-((3-(4-methoxyphenyl)-1,2,4-triazolo(3,4-a)phthalazin-6-yl)methylamino)-;87539-86-4;CHEMBL14214;SCHEMBL10664457;DTXSID801007619;LS-122489;1-{[3-(4-Methoxyphenyl)[1,2,4]triazolo[3,4-a]phthalazin-6-yl](methyl)amino}propan-2-ol

Suppliers and Price of 1-((3-(4-Methoxyphenyl)-1,2,4-triazolo(3,4-a)phthalazin-6-yl)methylamino)-2-propanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-((3-(4-Methoxyphenyl)-1,2,4-triazolo(3,4-a)phthalazin-6-yl)methylamino)-2-propanol

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.31g/cm³
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:363.16952493
Heavy Atom Count:27
Complexity:487

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CN(C)C1=NN2C(=NN=C2C3=CC=CC=C31)C4=CC=C(C=C4)OC)O

Technology Process of 1-((3-(4-Methoxyphenyl)-1,2,4-triazolo(3,4-a)phthalazin-6-yl)methylamino)-2-propanol

There total 3 articles about 1-((3-(4-Methoxyphenyl)-1,2,4-triazolo(3,4-a)phthalazin-6-yl)methylamino)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 16667-45-1
1-(methylamino)propan-2-ol

: 98123-77-4
6-chloro-3-(4-methoxy-phenyl)-[1,2,4]triazolo[3,4-a]phthalazine

: 87539-86-4
N-(2-hydroxypropyl)-3-(4-methoxyphenyl)-N-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-amine

Guidance literature:: With hydrogenchloride; potassium iodide; In ethanol; at 100 ℃; for 8h;
DOI:10.1021/jm00401a010

Reference yield:

: 51935-42-3,59275-72-8
1-chloro-4-hydrazinophthalazine

: 87539-86-4
N-(2-hydroxypropyl)-3-(4-methoxyphenyl)-N-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Et₃N / dioxane / 5 h / Heating

2: 57 percent / KI, HCl / ethanol / 8 h / 100 °C

With hydrogenchloride; triethylamine; potassium iodide; In 1,4-dioxane; ethanol;
DOI:10.1021/jm00401a010

Reference yield:

: 100-07-2
4-methoxy-benzoyl chloride

: 87539-86-4
N-(2-hydroxypropyl)-3-(4-methoxyphenyl)-N-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Et₃N / dioxane / 5 h / Heating

2: 57 percent / KI, HCl / ethanol / 8 h / 100 °C

With hydrogenchloride; triethylamine; potassium iodide; In 1,4-dioxane; ethanol;
DOI:10.1021/jm00401a010