L-Valinamide, N-methyl-N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S,2S)-1-[(1R)-2-carb oxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-

Base Information

Chemical Name:L-Valinamide, N-methyl-N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S,2S)-1-[(1R)-2-carb oxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-
CAS No.:920017-22-7
Molecular Formula:C29H47N3O7
Molecular Weight:549.708
Hs Code.:

Synonyms:Cbz-MeVal-Val-Dil;(3R,4S,5S)-4-({(S)-2-[(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-methyl-butyrylamino]-3-methyl-butyryl}-methyl-amino)-3-methoxy-5-methyl-heptanoic acid;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Valinamide, N-methyl-N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S,2S)-1-[(1R)-2-carb oxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-

Chemical Property:

Boiling Point:708.5±60.0 °C(Predicted)
PSA：125.48000
Density:1.113±0.06 g/cm3(Predicted)
LogP:4.17410

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Valinamide, N-methyl-N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S,2S)-1-[(1R)-2-carb oxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-

There total 7 articles about L-Valinamide, N-methyl-N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S,2S)-1-[(1R)-2-carb oxy-1-methoxyethyl]-2-methylbutyl]-N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 173441-13-9
Cbz-MeVal-Val-Dil-OtBu

: 920017-22-7
(5S,8S,11S,12R)-11-((S)-sec-butyl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatetradecan-14-oic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1248/cpb.43.1706

Reference yield:

: 135383-56-1
(3R,4S,5S)-4--3-methoxy-5-methylheptanoic acid

: 920017-22-7
(5S,8S,11S,12R)-11-((S)-sec-butyl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatetradecan-14-oic acid

Guidance literature:: Multi-step reaction with 6 steps

1: H₂SO₄ / CH₂Cl₂

2: H₂ / 5percent Pd/C / 2-methyl-propan-2-ol; H₂O / 2 h

3: 1,3-dicyclohexylcarbodiimide / CH₂Cl₂

4: H₂ / 5percent Pd/C / 2-methyl-propan-2-ol; H₂O / 2 h

5: diethyl phosphorocyanidate, Et₃N / dimethylformamide / a) 0 deg C, 4 h, b) RT, 16 h

6: trifluoroacetic acid / CH₂Cl₂ / 1 h / Ambient temperature

With diethyl cyanophosphonate; sulfuric acid; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1248/cpb.43.1706

Reference yield:

: 120205-58-5
tert-Butyl (3R,4S,5S)-3-methoxy-4--5-methylheptanoate

: 920017-22-7
(5S,8S,11S,12R)-11-((S)-sec-butyl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatetradecan-14-oic acid

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / 5percent Pd/C / 2-methyl-propan-2-ol; H₂O / 2 h

2: 1,3-dicyclohexylcarbodiimide / CH₂Cl₂

3: H₂ / 5percent Pd/C / 2-methyl-propan-2-ol; H₂O / 2 h

4: diethyl phosphorocyanidate, Et₃N / dimethylformamide / a) 0 deg C, 4 h, b) RT, 16 h

5: trifluoroacetic acid / CH₂Cl₂ / 1 h / Ambient temperature

With diethyl cyanophosphonate; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1248/cpb.43.1706