Technology Process of Z-N-Me-Val-Val-Dil-Dap-Doe
There total 12 articles about Z-N-Me-Val-Val-Dil-Dap-Doe which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
diethyl cyanophosphonate; triethylamine;
In
N,N-dimethyl-formamide;
a) 0 deg C, 2 h, b) RT, 16 h;
DOI:10.1248/cpb.43.1706
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 18 percent / LDA / tetrahydrofuran / 0.5 h / -78 °C
2: 41 percent / BF3*OEt2 / CH2Cl2
3: H2 / 5percent Pd/C / 2-methyl-propan-2-ol; H2O
4: benzotriazolyloxytris(dimethylamino)phosphonium hexafluorophosphate, iso-Pr2NEt / acetonitrile
5: HCl / dioxane / 1 h / Ambient temperature
6: 69 percent / diethyl phosphorocyanidate, Et3N / dimethylformamide / a) 0 deg C, 2 h, b) RT, 16 h
With
hydrogenchloride; diethyl cyanophosphonate; boron trifluoride diethyl etherate; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1248/cpb.43.1706
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 41 percent / BF3*OEt2 / CH2Cl2
2: H2 / 5percent Pd/C / 2-methyl-propan-2-ol; H2O
3: benzotriazolyloxytris(dimethylamino)phosphonium hexafluorophosphate, iso-Pr2NEt / acetonitrile
4: HCl / dioxane / 1 h / Ambient temperature
5: 69 percent / diethyl phosphorocyanidate, Et3N / dimethylformamide / a) 0 deg C, 2 h, b) RT, 16 h
With
hydrogenchloride; diethyl cyanophosphonate; boron trifluoride diethyl etherate; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1248/cpb.43.1706