3-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S)-1-(4-methoxyphenyl)eth yl]-5-oxo-, (3R,4S)-

Base Information

Chemical Name:3-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S)-1-(4-methoxyphenyl)eth yl]-5-oxo-, (3R,4S)-
CAS No.:920298-23-3
Molecular Formula:C19H26N2O6
Molecular Weight:378.425
Hs Code.:
Mol file:920298-23-3.mol

Synonyms:

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Chemical Property of 3-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S)-1-(4-methoxyphenyl)eth yl]-5-oxo-, (3R,4S)-

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S)-1-(4-methoxyphenyl)eth yl]-5-oxo-, (3R,4S)-

There total 9 articles about 3-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S)-1-(4-methoxyphenyl)eth yl]-5-oxo-, (3R,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 856410-14-5
methyl (3R,4S)-{4-(tert-butoxycarbonylamino)-1-[(1S)-1-(4-methoxyphenyl)ethyl]-5-oxopyrrolidin-3-yl}carboxylate

: 920298-23-3
(3R,4S)-{4-(tert-butoxycarbonylamino)-1-[(1S)-1-(4-methoxyphenyl)ethyl]-5-oxopyrrolidin-3-yl}carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 4h;
DOI:10.1002/ejoc.200700300

Reference yield:

: 856410-19-0
(3S,4R,1'S)-4-methoxycarbonyl-3-trichloroacetylamino-1-[1'-(4''-methoxyphenyl)ethyl]pyrrolidin-2-one

: 920298-23-3
(3R,4S)-{4-(tert-butoxycarbonylamino)-1-[(1S)-1-(4-methoxyphenyl)ethyl]-5-oxopyrrolidin-3-yl}carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq.NaOH / 24 h / 20 °C

1.2: 93 percent / HCl / pH 1

2.1: triethylamine / methanol / 12 h / 20 °C

2.2: 0.36 g / diethyl ether

3.1: 90 percent / aq.NaOH / methanol / 12 h / 20 °C

With sodium hydroxide; triethylamine; In methanol;
DOI:10.1039/b612071g

Reference yield:

: (3S,4R,1'S)-3-amino-2-oxo-1-[1'-(4-methoxyphenylethyl)]pyrrolidinecarboxylic acid

: 920298-23-3
(3R,4S)-{4-(tert-butoxycarbonylamino)-1-[(1S)-1-(4-methoxyphenyl)ethyl]-5-oxopyrrolidin-3-yl}carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / methanol / 12 h / 20 °C

1.2: 0.36 g / diethyl ether

2.1: 90 percent / aq.NaOH / methanol / 12 h / 20 °C

With sodium hydroxide; triethylamine; In methanol;
DOI:10.1039/b612071g