3-Pyrrolidinecarboxylic acid, 4-[[[(3R,4S)-4-[[[(3R,4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S )-1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S) -1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S)- 1-(4-methoxyphenyl)ethyl]-5-oxo-, (3R,4S)-

Base Information

Chemical Name:3-Pyrrolidinecarboxylic acid, 4-[[[(3R,4S)-4-[[[(3R,4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S )-1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S) -1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S)- 1-(4-methoxyphenyl)ethyl]-5-oxo-, (3R,4S)-
CAS No.:920298-34-6
Molecular Formula:C47H58N6O12
Molecular Weight:899.011
Hs Code.:

3-Pyrrolidinecarboxylic acid,
4-[[[(3R,4S)-4-[[[(3R,4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S
)-1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S)
-1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S)-
1-(4-methoxyphenyl)ethyl]-5-oxo-, (3R,4S)-

Synonyms:

Suppliers and Price of 3-Pyrrolidinecarboxylic acid, 4-[[[(3R,4S)-4-[[[(3R,4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S )-1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S) -1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S)- 1-(4-methoxyphenyl)ethyl]-5-oxo-, (3R,4S)-

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Chemical Property of 3-Pyrrolidinecarboxylic acid, 4-[[[(3R,4S)-4-[[[(3R,4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S )-1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S) -1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S)- 1-(4-methoxyphenyl)ethyl]-5-oxo-, (3R,4S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Pyrrolidinecarboxylic acid, 4-[[[(3R,4S)-4-[[[(3R,4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S )-1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S) -1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S)- 1-(4-methoxyphenyl)ethyl]-5-oxo-, (3R,4S)-

There total 5 articles about 3-Pyrrolidinecarboxylic acid, 4-[[[(3R,4S)-4-[[[(3R,4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S )-1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S) -1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S)- 1-(4-methoxyphenyl)ethyl]-5-oxo-, (3R,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 920298-32-4
4-({4-({4-tert-butoxycarbonylamino-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carbonyl}-amino)-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carbonyl}-amino)-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

: 920298-34-6
4-({4-({4-tert-butoxycarbonylamino-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carbonyl}-amino)-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carbonyl}-amino)-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; for 12h;
DOI:10.1039/b612071g

Reference yield:

: 920298-23-3
(3R,4S)-{4-(tert-butoxycarbonylamino)-1-[(1S)-1-(4-methoxyphenyl)ethyl]-5-oxopyrrolidin-3-yl}carboxylic acid

: 920298-34-6
4-({4-({4-tert-butoxycarbonylamino-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carbonyl}-amino)-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carbonyl}-amino)-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / triethylamine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 12 h / 20 °C

2: 90 percent / aq.NaOH / methanol / 12 h

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1039/b612071g

Reference yield:

: 856410-19-0
(3S,4R,1'S)-4-methoxycarbonyl-3-trichloroacetylamino-1-[1'-(4''-methoxyphenyl)ethyl]pyrrolidin-2-one

: 920298-34-6
4-({4-({4-tert-butoxycarbonylamino-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carbonyl}-amino)-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carbonyl}-amino)-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: aq.NaOH / 24 h / 20 °C

1.2: 93 percent / HCl / pH 1

2.1: triethylamine / methanol / 12 h / 20 °C

2.2: 0.36 g / diethyl ether

3.1: 90 percent / aq.NaOH / methanol / 12 h / 20 °C

4.1: 67 percent / triethylamine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 12 h / 20 °C

5.1: 90 percent / aq.NaOH / methanol / 12 h

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1039/b612071g