6-(acridin-9-ylamino)-1-[4-[bis(2-chloroethyl)amino]phenyl]hexan-1-one

Base Information

Chemical Name:6-(acridin-9-ylamino)-1-[4-[bis(2-chloroethyl)amino]phenyl]hexan-1-one
CAS No.:125173-79-7
Molecular Formula:C29H31 Cl2 N3 O
Molecular Weight:508.4819
Hs Code.:
Mol file:125173-79-7.mol

Synonyms:6-(9-Acridinylamino)-1-(4-(bis(2-chloroethyl)amino)phenyl)-1-hexanone;1-Hexanone,6-(9-acridinylamino)-1-[4-[bis(2-chloroethyl)amino]phenyl];

Suppliers and Price of 6-(acridin-9-ylamino)-1-[4-[bis(2-chloroethyl)amino]phenyl]hexan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 6-(acridin-9-ylamino)-1-[4-[bis(2-chloroethyl)amino]phenyl]hexan-1-one

Chemical Property:

Vapor Pressure:9.17E-21mmHg at 25°C
Boiling Point:723.1°Cat760mmHg
Flash Point:391.1°C
PSA：48.46000
Density:1.252g/cm³
LogP:6.94910

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-(acridin-9-ylamino)-1-[4-[bis(2-chloroethyl)amino]phenyl]hexan-1-one

There total 9 articles about 6-(acridin-9-ylamino)-1-[4-[bis(2-chloroethyl)amino]phenyl]hexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 10228-90-7
9-methoxyacridine

: 125499-16-3
6-Amino-1-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-hexan-1-one

: 125173-79-7
6-(Acridin-9-ylamino)-1-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-hexan-1-one

Guidance literature:: In methanol; at 20 ℃; for 24h;
DOI:10.1021/jm00166a015

Reference yield:

: 38968-78-4
2-(4'-nitro)benzoylcyclohexanone

: 125173-79-7
6-(Acridin-9-ylamino)-1-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-hexan-1-one

Guidance literature:: Multi-step reaction with 10 steps

1: 75 percent / H₂ / Pd/C / methanol

2: 61 percent / KOH, H₂O / 1.25 h / Heating

3: 87 percent / H₂SO₄

4: 38 percent / acetic acid; tetrahydrofuran / 168 h / 20 °C

5: Et₃N / CH₂Cl₂ / 3 h / 20 °C

6: NaCl / dimethylformamide / 0.08 h / Heating

7: conc. HCl / 1 h / 80 °C

8: Et₃N / acetone / 0.25 h / 0 °C

9: 1.) NaN₃, 2.) 8 M HCl / 1.) Me₂CO, H₂O, 0 deg, 30 min, 2.) reflux, 10 min

10: 74 percent / methanol / 24 h / 20 °C

With hydrogenchloride; potassium hydroxide; sodium azide; sulfuric acid; water; hydrogen; triethylamine; sodium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00166a015

Reference yield:

: 125174-01-8
6-(4-aminobenzoyl)hexanoic acid

: 125173-79-7
6-(Acridin-9-ylamino)-1-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-hexan-1-one

Guidance literature:: Multi-step reaction with 8 steps

1: 87 percent / H₂SO₄

2: 38 percent / acetic acid; tetrahydrofuran / 168 h / 20 °C

3: Et₃N / CH₂Cl₂ / 3 h / 20 °C

4: NaCl / dimethylformamide / 0.08 h / Heating

5: conc. HCl / 1 h / 80 °C

6: Et₃N / acetone / 0.25 h / 0 °C

7: 1.) NaN₃, 2.) 8 M HCl / 1.) Me₂CO, H₂O, 0 deg, 30 min, 2.) reflux, 10 min

8: 74 percent / methanol / 24 h / 20 °C

With hydrogenchloride; sodium azide; sulfuric acid; triethylamine; sodium chloride; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00166a015