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10228-90-7

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10228-90-7 Usage

General Description

9-methoxyacridine is a chemical compound with the molecular formula C14H11NO, which belongs to the acridine family. It is a derivative of acridine, a nitrogen-containing polycyclic aromatic compound. 9-methoxyacridine is a yellow crystalline solid and is often used as a fluorescent dye in biological and chemical research applications. It has been found to exhibit anticancer and antibacterial properties, making it a potential candidate for therapeutic development. The compound is also used in the production of pharmaceuticals and in the preparation of organic compounds. Overall, 9-methoxyacridine has a range of potential applications in both research and industrial settings due to its unique chemical properties.

Check Digit Verification of cas no

The CAS Registry Mumber 10228-90-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,2,2 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 10228-90:
(7*1)+(6*0)+(5*2)+(4*2)+(3*8)+(2*9)+(1*0)=67
67 % 10 = 7
So 10228-90-7 is a valid CAS Registry Number.
InChI:InChI=1/C14H11NO/c1-16-14-10-6-2-4-8-12(10)15-13-9-5-3-7-11(13)14/h2-9H,1H3

10228-90-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 9-methoxyacridine

1.2 Other means of identification

Product number -
Other names 9-Methoxy-acridin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10228-90-7 SDS

10228-90-7Relevant articles and documents

9-substituted acridines. Demethoxylation of 9-methoxyacridine and dechlorination of 9-chloroacridine in hydroxylic solvents

Kalatzis, Evangelos,Konga, Zoi,Geronikolou, Konstantina

, p. 961 - 965 (1996)

In methanol-water mixtures containing sodium or potassium hydroxide (up to 2.00M) the demethoxylation of 9-methoxyacridine to 9-acridone is of first order in both the free form of 9-methoxyacridine and the hydroxyl ion. The rate of the reaction is increased with an increase in the concentration of water. Sodium perchlorate has a small retarding effect on the reaction. In methanol-water mixtures containing perchloric or hydrochloric acid (up to 3.45M) the demethoxylation is of first order with respect to the protonated form of 9-methoxyacridine. The rate of the reaction decreases with an increase in the concentration of the acid or of sodium perchlorate, but when the concentration of water is increased (≈1.7 to 50M) and that of the acid is not changed, it reaches a maximum value in mixtures containing 8 to 10M-water. The dechlorination of 9-chloroacridine to 9-methoxyacridine in methanol containing sodium hydroxide or methoxide (up to 0.31M) is of first order in both the 9-chloroacridine and the hydroxyl or methoxyl ions.

Spectrophotometric determination of cycloserine with 9-methoxyacridine

Stewart,Yoo

, p. 452 - 454 (1988)

Spectrophotometric assay for cycloserine based on the interaction of the drug with 9-methoxyacridine as a chromogenic agent is described. The highly colored substituted acridine product was identified as 9-(d-4-imino-3-isoxazolidinone)acridine. Color development was affected by time and temperature of heating and by the quantity of 9-methoxyacridine reagent utilized. The absorbance at 438 nm is linearly proportional to concentrations cycloserine with a detection limit of 0.3 μg/mL. The optimum range for the assay of cycloserine was from 5.0 x 10-6 to 3.0 x 10-4 M (correlation coefficient = 0.9999, n = 6). When applied to cycloserine capsules labeled to contain 250 mg, the proposed method gave mean recoveries of 101.84 ± 0.48%. The procedure is sufficiently sensitive, precise, and accurate for the determination of cycloserine in its dosage form.

Palladium-catalyzed intermolecular decarboxylative coupling of 2-phenylbenzoic acids with alkynes via C-H and C-C bond activation

Wang, Congyang,Rakshit, Souvik,Glorius, Frank

supporting information; experimental part, p. 14006 - 14008 (2010/12/24)

A novel protocol for palladium-catalyzed intermolecular formal [4 + 2] annulation of 2-phenylbenzoic acids with alkynes is described. Acridine is shown to be essential for the high reaction efficiency. Phenanthrene derivatives are formed in moderate to good yields without coupling (pseudo)halides or organometallic species.

Sulfonated diarylrhodamine dyes

-

, (2008/06/13)

Sulfonated diarylrhodamine compounds are useful as fluorescent labels of nucleosides, nucleotides, polynucleotides, and polypeptides. The compounds find particular application in the area of fluorescent nucleic acid analysis, e.g., automated DNA sequencing and fragment analysis, detection of probe hybridization in hybridization arrays, detection of nucleic acid amplification products, and the like.

Biological active acridine derivatives, part 3: Aridinylaminoacids and their esters: Synthesis and cytostatic activity

Lyakhov,Suveyzdis,Bykhovskaya,Isko,Andronati,Litvinova

, p. 560 - 561 (2007/10/03)

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