4-Penten-2-one, 1-[(2S,4S,6S)-2-phenyl-6-[3-(phenylmethoxy)propyl]-1,3-dioxan-4-yl]-

Base Information

Chemical Name:4-Penten-2-one, 1-[(2S,4S,6S)-2-phenyl-6-[3-(phenylmethoxy)propyl]-1,3-dioxan-4-yl]-
CAS No.:921207-70-7
Molecular Formula:C25H30O4
Molecular Weight:394.511
Hs Code.:

Synonyms:

Suppliers and Price of 4-Penten-2-one, 1-[(2S,4S,6S)-2-phenyl-6-[3-(phenylmethoxy)propyl]-1,3-dioxan-4-yl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-Penten-2-one, 1-[(2S,4S,6S)-2-phenyl-6-[3-(phenylmethoxy)propyl]-1,3-dioxan-4-yl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Penten-2-one, 1-[(2S,4S,6S)-2-phenyl-6-[3-(phenylmethoxy)propyl]-1,3-dioxan-4-yl]-

There total 12 articles about 4-Penten-2-one, 1-[(2S,4S,6S)-2-phenyl-6-[3-(phenylmethoxy)propyl]-1,3-dioxan-4-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: N-methoxy-N-methyl 2-[(2S,4S,6S)-6-(3-benzyloxy-propyl)-2-phenyl-1,3-dioxan-4-yl]acetamide

: 2622-05-1
allylmagnesium bromide

: 921207-70-7
5-{(2S,4S,6S)-6-[3-(benzyloxy)propyl]-2-phenyl-1,3-dioxan-4-yl}-1-penten-4-one

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1021/ol062595u

Reference yield: 79.0%

: 5-{(2S,4R,6S)-6-[3-(benzyloxy)propyl]-2-phenyl-1,3-dioxan-4-yl}pent-1-en-4-ol

: 921207-70-7
5-{(2S,4S,6S)-6-[3-(benzyloxy)propyl]-2-phenyl-1,3-dioxan-4-yl}-1-penten-4-one

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide; at 25 ℃; for 4h;
DOI:10.1055/s-2007-965979

Reference yield:

: 565473-04-3
((hept-6-yn-1-yloxy)methyl)benzene

: 921207-70-7
5-{(2S,4S,6S)-6-[3-(benzyloxy)propyl]-2-phenyl-1,3-dioxan-4-yl}-1-penten-4-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 93 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C

2.1: Ph₃P; phenol / benzene / 12 h / 50 °C

2.2: 95 percent / MeI / diethyl ether / 12 h / Heating

3.1: K₃Fe(CN)6; K₂CO₃; MeSO₂NH₂ / (DHQD)2-PHAL; OsO₄ / 2-methyl-propan-2-ol; H₂O / 0 °C

3.2: MeI / diethyl ether / 12 h / Heating

3.3: 27.9 g / pyridine; DMAP / CH₂Cl₂ / -78 - 0 °C

4.1: 90 percent / PPh₃; triethylamine; HCOOH / Pd₂(dba)3*CHCl₃ / tetrahydrofuran / 20 °C

5.1: 59 percent / t-BuOK / tetrahydrofuran / 0 °C

6.1: 89 percent / isopropylmagnesium chloride / tetrahydrofuran; diethyl ether / 0.5 h / cooling

7.1: 86 percent / tetrahydrofuran / 0.5 h / 0 °C

With n-butyllithium; formic acid; methanesulfonamide; potassium tert-butylate; isopropylmagnesium chloride; potassium carbonate; triethylamine; triphenylphosphine; potassium hexacyanoferrate(III); phenol; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; osmium(VIII) oxide; 1,4-bis(9-O-dihydroquinidine)phthalazine; In tetrahydrofuran; diethyl ether; hexane; water; tert-butyl alcohol; benzene; 2.1: Trost isomerization / 3.1: Sharpless asymmetric dihydroxylation;
DOI:10.1021/ol062595u