Benzoic acid, 2-methoxy-6-[(1E,4R)-4-(phenylmethoxy)-5-[(2S,4R,6S)-2-phenyl-6-[3-( phenylmethoxy)propyl]-1,3-dioxan-4-yl]-1-penten-1-yl]-, methyl ester

Base Information

Chemical Name:Benzoic acid, 2-methoxy-6-[(1E,4R)-4-(phenylmethoxy)-5-[(2S,4R,6S)-2-phenyl-6-[3-( phenylmethoxy)propyl]-1,3-dioxan-4-yl]-1-penten-1-yl]-, methyl ester
CAS No.:921207-73-0
Molecular Formula:C41H46O7
Molecular Weight:650.812
Hs Code.:

Benzoic acid,
2-methoxy-6-[(1E,4R)-4-(phenylmethoxy)-5-[(2S,4R,6S)-2-phenyl-6-[3-(
phenylmethoxy)propyl]-1,3-dioxan-4-yl]-1-penten-1-yl]-, methyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzoic acid, 2-methoxy-6-[(1E,4R)-4-(phenylmethoxy)-5-[(2S,4R,6S)-2-phenyl-6-[3-( phenylmethoxy)propyl]-1,3-dioxan-4-yl]-1-penten-1-yl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 2-methoxy-6-[(1E,4R)-4-(phenylmethoxy)-5-[(2S,4R,6S)-2-phenyl-6-[3-( phenylmethoxy)propyl]-1,3-dioxan-4-yl]-1-penten-1-yl]-, methyl ester

There total 18 articles about Benzoic acid, 2-methoxy-6-[(1E,4R)-4-(phenylmethoxy)-5-[(2S,4R,6S)-2-phenyl-6-[3-( phenylmethoxy)propyl]-1,3-dioxan-4-yl]-1-penten-1-yl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 921207-63-8
methyl 2-methoxy-6-vinylbenzoate

: 921207-64-9
(4R)-4-benzyloxy-5-[(2S,4R,6S)-6-(3-benzyloxy-propyl)-2-phenyl-1,3-dioxan-4-yl]pent-1-ene

: 921207-73-0
methyl 2-{(1E,4R)-4-benzyloxy-5-[(2S,4R,6S)-6-(3-benzyloxy-propyl)-2-phenyl-1,3-dioxan-4-yl]pent-1-enyl}-6-methoxy-benzoate

Guidance literature:: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 24h; Heating;
DOI:10.1021/ol062595u

Reference yield:

: 915141-48-9
2-[(2S,4S,6S)-6-(3-benzyloxy-propyl)-2-phenyl-1,3-dioxan-4-yl]acetaldehyde

: 921207-73-0
methyl 2-{(1E,4R)-4-benzyloxy-5-[(2S,4R,6S)-6-(3-benzyloxy-propyl)-2-phenyl-1,3-dioxan-4-yl]pent-1-enyl}-6-methoxy-benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 24 h / -10 °C

2: 97 percent / KH; tetrabutylammonium iodide / diethyl ether; tetrahydrofuran / 3 h / 0 °C

3: 86 percent / second-generation Grubbs' catalyst / CH₂Cl₂ / 24 h / Heating

With tetra-(n-butyl)ammonium iodide; potassium hydride; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ol062595u

Reference yield:

: 565473-04-3
((hept-6-yn-1-yloxy)methyl)benzene

: 921207-73-0
methyl 2-{(1E,4R)-4-benzyloxy-5-[(2S,4R,6S)-6-(3-benzyloxy-propyl)-2-phenyl-1,3-dioxan-4-yl]pent-1-enyl}-6-methoxy-benzoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: 93 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C

2.1: Ph₃P; phenol / benzene / 12 h / 50 °C

2.2: 95 percent / MeI / diethyl ether / 12 h / Heating

3.1: K₃Fe(CN)6; K₂CO₃; MeSO₂NH₂ / (DHQD)2-PHAL; OsO₄ / 2-methyl-propan-2-ol; H₂O / 0 °C

3.2: MeI / diethyl ether / 12 h / Heating

3.3: 27.9 g / pyridine; DMAP / CH₂Cl₂ / -78 - 0 °C

4.1: 90 percent / PPh₃; triethylamine; HCOOH / Pd₂(dba)3*CHCl₃ / tetrahydrofuran / 20 °C

5.1: 59 percent / t-BuOK / tetrahydrofuran / 0 °C

6.1: 89 percent / isopropylmagnesium chloride / tetrahydrofuran; diethyl ether / 0.5 h / cooling

7.1: 86 percent / tetrahydrofuran / 0.5 h / 0 °C

8.1: 76 percent / L-Selectride / tetrahydrofuran / 3 h / -100 °C

9.1: 97 percent / KH; tetrabutylammonium iodide / diethyl ether; tetrahydrofuran / 3 h / 0 °C

10.1: 86 percent / second-generation Grubbs' catalyst / CH₂Cl₂ / 24 h / Heating

With n-butyllithium; formic acid; methanesulfonamide; potassium tert-butylate; isopropylmagnesium chloride; tetra-(n-butyl)ammonium iodide; potassium hydride; L-Selectride; potassium carbonate; triethylamine; triphenylphosphine; potassium hexacyanoferrate(III); phenol; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; osmium(VIII) oxide; 1,4-bis(9-O-dihydroquinidine)phthalazine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; tert-butyl alcohol; benzene; 2.1: Trost isomerization / 3.1: Sharpless asymmetric dihydroxylation;
DOI:10.1021/ol062595u