2-BROMO-5-CHLORO-4-(DIMETHOXYMETHYL)PYRIDINE

Base Information

Chemical Name:2-BROMO-5-CHLORO-4-(DIMETHOXYMETHYL)PYRIDINE
CAS No.:921630-15-1
Molecular Formula:C₈H₉BrClNO₂
Molecular Weight:266.522
Hs Code.:
Mol file:921630-15-1.mol

Synonyms:2-bromo-5-chloropyridine-4-dimethoxymethylpyridine;2-bromo-5-chloro-4-dimethoxymethylpyridine;

Suppliers and Price of 2-BROMO-5-CHLORO-4-(DIMETHOXYMETHYL)PYRIDINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

American Custom Chemicals Corporation
2-BROMO-5-CHLORO-4-(DIMETHOXYMETHYL)PYRIDINE 95.00%
5MG
$ 503.82

Total 0 raw suppliers

Chemical Property of 2-BROMO-5-CHLORO-4-(DIMETHOXYMETHYL)PYRIDINE

Chemical Property:

PSA：31.35000
LogP:2.78890

Purity/Quality:: 2-BROMO-5-CHLORO-4-(DIMETHOXYMETHYL)PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 2-BROMO-5-CHLORO-4-(DIMETHOXYMETHYL)PYRIDINE

There total 2 articles about 2-BROMO-5-CHLORO-4-(DIMETHOXYMETHYL)PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 921630-14-0
2-bromo-5-chloro-pyridine-4-carbaldehyde

: 149-73-5
trimethyl orthoformate

: 921630-15-1
2-bromo-5-chloropyridine-4-dimethoxymethylpyridine

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 3h; Heating / reflux;

Reference yield:

: 40473-01-6
2-Bromo-5-chloro-pyridine

: 921630-15-1
2-bromo-5-chloropyridine-4-dimethoxymethylpyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -5 °C

1.2: 0.75 h / -70 °C

2.1: toluene-4-sulfonic acid / methanol / 3 h / Heating / reflux

With n-butyllithium; toluene-4-sulfonic acid; diisopropylamine; In tetrahydrofuran; methanol; hexane;

Reference yield:

: 921630-15-1
2-bromo-5-chloropyridine-4-dimethoxymethylpyridine

: 5-((5-chloro-2-(3-methoxypropyl)pyridin-4-yl)cyclopropylcarbamoyl).4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: iodine; magnesium / tetrahydrofuran / 0.33 h / Heating / reflux

1.2: 2.5 h / 0 °C / Heating / reflux

2.1: hydrogenchloride / water / 2 h / 80 °C

2.2: 0 °C / pH 10

3.1: methanol / 20 °C

3.2: 0 - 20 °C

4.1: lithium hydroxide / tetrahydrofuran; water / 72 h / 60 °C

4.2: 20 °C

4.3: 48 h / 20 °C

With hydrogenchloride; lithium hydroxide; iodine; magnesium; In tetrahydrofuran; methanol; water;